Patients with Diffuse Axonal Injury Can Recover to a Favorable Long-Term Functional and Quality of Life Outcome

Marleen van Eijck*, Joukje van der Naalt, Mariska de Jongh, Guus Schoonman, Annemarie Oldenbeuving, Jo Peluso, Jolanda de Vries, Gerwin Roks

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Second, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients >= 16 years of age with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Outcome Scale Extended (GOSE) at long-term follow-up. Second, the HRQL was assessed with the Quality Of Life after Brain Injury (QOLIBRI) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72%), median follow-up was 54 months (range 14-100); and 51% had a favorable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness

Original languageEnglish
Pages (from-to)2357-2364
Number of pages8
JournalJournal of Neurotrauma
Volume35
Issue number20
DOIs
Publication statusPublished - Oct-2018

Keywords

  • DAI
  • GOSE
  • HRQL
  • QOLIBRI
  • TBI
  • TRAUMATIC BRAIN-INJURY
  • CLOSED-HEAD INJURY
  • LONGITUDINAL MRI
  • CORPUS-CALLOSUM
  • LESIONS
  • PROGNOSIS
  • MODERATE
  • PREDICTION
  • IMPACT
  • SCALE

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