Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

Qian Wang, Angelina Osipyan, Markella Konstantinidou, Roberto Butera, Kumchok C. Mgimpatsang, Svitlana V. Shishkina, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Here we describe a facile, tandem synthetic route for indolo[3,2-c]quinolinones, a class of natural alkaloid analogues of high biological significance. A Ugi four-component reaction with indole-2-carboxylic acid and an aniline followed by a Pd-catalyzed cyclization yields tetracyclic indoloquinolines in good to moderate yields. Commercially available building blocks yield highly diverse analogues in just two simple steps.
Original languageEnglish
Pages (from-to)12148-12156
Number of pages9
JournalThe Journal of Organic Chemistry
Volume84
Issue number18
DOIs
Publication statusPublished - 20-Sep-2019

Keywords

  • article
  • catalysis
  • 2 indolecarboxylic acid
  • alkaloid
  • aniline
  • MULTICOMPONENT REACTIONS
  • INHIBITORS
  • DESIGN

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