Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005

Rosa Laura E. van Loon; Marcus T. R. Roofthooft; Hans L. Hillege; Arend D. J. ten Harkel; Magdalena van Osch-Gevers; Tammo Delhaas; Livia Kapusta; Jan L. M. Strengers; Lukas Rammeloo; Sally-Ann B. Clur; Barbara J. M. Mulder; Rolf M. F. Berger

doi:10.1161/CIRCULATIONAHA.110.969584

Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005

Rosa Laura E. van Loon
, Marcus T. R. Roofthooft
, Hans L. Hillege
, Arend D. J. ten Harkel
, Magdalena van Osch-Gevers
, Tammo Delhaas
, Livia Kapusta
, Jan L. M. Strengers
, Lukas Rammeloo
, Sally-Ann B. Clur
, Barbara J. M. Mulder
, Rolf M. F. Berger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

282 Citations (Scopus)

Abstract

Background-Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH.

Methods and Results-Two registries were used to retrospectively identify children (0-17 years) with PH. Overall, 3263 pediatric patients were identified with PH due to left heart disease (n = 160; 5%), lung disease/hypoxemia (n = 253; 8%), thromboembolic disease (n = 5;

Conclusions-Pediatric PH is characterized by various age-specific diagnoses, the majority of which comprise transient forms of PAH. Incidence of pediatric iPAH is lower whereas incidence of pediatric PAH-CHD is higher than reported in adults. Pediatric PAH-CHD represents a heterogeneous group with highly variable clinical courses. (Circulation. 2011;124:17551764.)

Original language	English
Pages (from-to)	1755-U136
Number of pages	13
Journal	Circulation
Volume	124
Issue number	16
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.969584
Publication status	Published - 18-Oct-2011

Keywords

pulmonary hypertension
pediatric
epidemiology
incidence
prevalence
CONGENITAL CARDIAC-DISEASE
ARTERIAL-HYPERTENSION
EISENMENGER-SYNDROME
HEART-DISEASE
SURVIVAL
REGISTRY
ADULTS
CHILDREN
CLASSIFICATION

Access to Document

10.1161/CIRCULATIONAHA.110.969584

Handle.net

Persistent link

Cite this

van Loon, R. L. E., Roofthooft, M. T. R., Hillege, H. L., ten Harkel, A. D. J., van Osch-Gevers, M., Delhaas, T., Kapusta, L., Strengers, J. L. M., Rammeloo, L., Clur, S.-A. B., Mulder, B. J. M., & Berger, R. M. F. (2011). Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005. Circulation, 124(16), 1755-U136. https://doi.org/10.1161/CIRCULATIONAHA.110.969584

@article{a22faf81a0904e3d841950140a6dff3b,

title = "Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005",

abstract = "Background-Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH.Methods and Results-Two registries were used to retrospectively identify children (0-17 years) with PH. Overall, 3263 pediatric patients were identified with PH due to left heart disease (n = 160; 5\%), lung disease/hypoxemia (n = 253; 8\%), thromboembolic disease (n = 5;Conclusions-Pediatric PH is characterized by various age-specific diagnoses, the majority of which comprise transient forms of PAH. Incidence of pediatric iPAH is lower whereas incidence of pediatric PAH-CHD is higher than reported in adults. Pediatric PAH-CHD represents a heterogeneous group with highly variable clinical courses. (Circulation. 2011;124:17551764.)",

keywords = "pulmonary hypertension, pediatric, epidemiology, incidence, prevalence, CONGENITAL CARDIAC-DISEASE, ARTERIAL-HYPERTENSION, EISENMENGER-SYNDROME, HEART-DISEASE, SURVIVAL, REGISTRY, ADULTS, CHILDREN, CLASSIFICATION",

author = "\{van Loon\}, \{Rosa Laura E.\} and Roofthooft, \{Marcus T. R.\} and Hillege, \{Hans L.\} and \{ten Harkel\}, \{Arend D. J.\} and \{van Osch-Gevers\}, Magdalena and Tammo Delhaas and Livia Kapusta and Strengers, \{Jan L. M.\} and Lukas Rammeloo and Clur, \{Sally-Ann B.\} and Mulder, \{Barbara J. M.\} and Berger, \{Rolf M. F.\}",

year = "2011",

month = oct,

day = "18",

doi = "10.1161/CIRCULATIONAHA.110.969584",

language = "English",

volume = "124",

pages = "1755--U136",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "16",

}

van Loon, RLE, Roofthooft, MTR, Hillege, HL, ten Harkel, ADJ, van Osch-Gevers, M, Delhaas, T, Kapusta, L, Strengers, JLM, Rammeloo, L, Clur, S-AB, Mulder, BJM & Berger, RMF 2011, 'Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005', Circulation, vol. 124, no. 16, pp. 1755-U136. https://doi.org/10.1161/CIRCULATIONAHA.110.969584

TY - JOUR

T1 - Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005

AU - van Loon, Rosa Laura E.

AU - Roofthooft, Marcus T. R.

AU - Hillege, Hans L.

AU - ten Harkel, Arend D. J.

AU - van Osch-Gevers, Magdalena

AU - Delhaas, Tammo

AU - Kapusta, Livia

AU - Strengers, Jan L. M.

AU - Rammeloo, Lukas

AU - Clur, Sally-Ann B.

AU - Mulder, Barbara J. M.

AU - Berger, Rolf M. F.

PY - 2011/10/18

Y1 - 2011/10/18

N2 - Background-Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH.Methods and Results-Two registries were used to retrospectively identify children (0-17 years) with PH. Overall, 3263 pediatric patients were identified with PH due to left heart disease (n = 160; 5%), lung disease/hypoxemia (n = 253; 8%), thromboembolic disease (n = 5;Conclusions-Pediatric PH is characterized by various age-specific diagnoses, the majority of which comprise transient forms of PAH. Incidence of pediatric iPAH is lower whereas incidence of pediatric PAH-CHD is higher than reported in adults. Pediatric PAH-CHD represents a heterogeneous group with highly variable clinical courses. (Circulation. 2011;124:17551764.)

AB - Background-Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH.Methods and Results-Two registries were used to retrospectively identify children (0-17 years) with PH. Overall, 3263 pediatric patients were identified with PH due to left heart disease (n = 160; 5%), lung disease/hypoxemia (n = 253; 8%), thromboembolic disease (n = 5;Conclusions-Pediatric PH is characterized by various age-specific diagnoses, the majority of which comprise transient forms of PAH. Incidence of pediatric iPAH is lower whereas incidence of pediatric PAH-CHD is higher than reported in adults. Pediatric PAH-CHD represents a heterogeneous group with highly variable clinical courses. (Circulation. 2011;124:17551764.)

KW - pulmonary hypertension

KW - pediatric

KW - epidemiology

KW - incidence

KW - prevalence

KW - CONGENITAL CARDIAC-DISEASE

KW - ARTERIAL-HYPERTENSION

KW - EISENMENGER-SYNDROME

KW - HEART-DISEASE

KW - SURVIVAL

KW - REGISTRY

KW - ADULTS

KW - CHILDREN

KW - CLASSIFICATION

U2 - 10.1161/CIRCULATIONAHA.110.969584

DO - 10.1161/CIRCULATIONAHA.110.969584

M3 - Article

SN - 0009-7322

VL - 124

SP - 1755-U136

JO - Circulation

JF - Circulation

IS - 16

ER -

Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this