Pediocin PA-1, a wide-spectrum bacteriocin from lactic acid bacteria

JM Rodriguez*, MI Martinez, J Kok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademic

162 Citations (Scopus)
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Abstract

Pediocin PA-1 is a broad-spectrum lactic acid bacteria bacteriocin that shows a particularly strong activity against Listeria monocytogenes, a foodborne pathogen of special concern among the food industries. This antimicrobial peptide is the most extensively studied class IIa (or pediocin family) bacteriocin, and it has been sufficiently well characterized to be used as a food biopreservative. This review focuses on the progress that have been made in the elucidation of its structure, mode of action, and biosynthesis, and includes an overview of its applications in food systems. The aspects that need further research are also addressed. In the future, protein engineering, genetic engineering and/or chemical synthesis may lead to the development of new antimicrobial peptides with improved properties, based on some features of the pediocin PA-1 molecule.
Original languageEnglish
Pages (from-to)91-121
Number of pages31
JournalCritical Reviews in Food Science and Nutrition
Volume42
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • pediocin PA-1
  • bacteriocins
  • lactic acid bacteria
  • food preservatives
  • antimicrobials
  • food safety
  • Listeria monocytogenes
  • PEDIOCOCCUS-ACIDILACTICI-H
  • GRAM-POSITIVE BACTERIA
  • MONOCYTOGENES SCOTT-A
  • CONTROL LISTERIA-MONOCYTOGENES
  • PROTON MOTIVE FORCE
  • LACTOBACILLUS-PLANTARUM WHE-92
  • PLASMID-ENCODING BACTERIOCIN
  • PEPTIDE ANTIBIOTIC NISIN
  • LACTOCOCCUS-LACTIS
  • CARNOBACTERIUM-PISCICOLA

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