Pelvic organ prolapse and collagen-associated disorders

Karin Lammers; Sabrina L Lince; Marian A Spath; Léon C L T van Kempen; Jan C M Hendriks; Mark E Vierhout; Kirsten B Kluivers

doi:10.1007/s00192-011-1532-y

Pelvic organ prolapse and collagen-associated disorders

Karin Lammers, Sabrina L Lince, Marian A Spath, Léon C L T van Kempen, Jan C M Hendriks, Mark E Vierhout, Kirsten B Kluivers

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.

METHODS: In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.

RESULTS: POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).

CONCLUSIONS: POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.

Original language	English
Pages (from-to)	313-319
Number of pages	7
Journal	International urogynecology journal
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/s00192-011-1532-y
Publication status	Published - 2012
Externally published	Yes

Keywords

Aged
Aged, 80 and over
Case-Control Studies
Cohort Studies
Collagen Diseases/epidemiology
Comorbidity
Female
Humans
Joint Instability/epidemiology
Middle Aged
Netherlands/epidemiology
Pelvic Organ Prolapse/epidemiology
Prevalence
Varicose Veins/epidemiology

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title = "Pelvic organ prolapse and collagen-associated disorders",

abstract = "INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.METHODS: In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.RESULTS: POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).CONCLUSIONS: POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.",

keywords = "Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Collagen Diseases/epidemiology, Comorbidity, Female, Humans, Joint Instability/epidemiology, Middle Aged, Netherlands/epidemiology, Pelvic Organ Prolapse/epidemiology, Prevalence, Varicose Veins/epidemiology",

author = "Karin Lammers and Lince, {Sabrina L} and Spath, {Marian A} and {van Kempen}, {L{\'e}on C L T} and Hendriks, {Jan C M} and Vierhout, {Mark E} and Kluivers, {Kirsten B}",

year = "2012",

doi = "10.1007/s00192-011-1532-y",

language = "English",

volume = "23",

pages = "313--319",

journal = "International urogynecology journal",

issn = "0937-3462",

publisher = "SPRINGER LONDON LTD",

number = "3",

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TY - JOUR

T1 - Pelvic organ prolapse and collagen-associated disorders

AU - Lammers, Karin

AU - Lince, Sabrina L

AU - Spath, Marian A

AU - van Kempen, Léon C L T

AU - Hendriks, Jan C M

AU - Vierhout, Mark E

AU - Kluivers, Kirsten B

PY - 2012

Y1 - 2012

N2 - INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.METHODS: In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.RESULTS: POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).CONCLUSIONS: POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.

AB - INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.METHODS: In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.RESULTS: POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).CONCLUSIONS: POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Cohort Studies

KW - Collagen Diseases/epidemiology

KW - Comorbidity

KW - Female

KW - Humans

KW - Joint Instability/epidemiology

KW - Middle Aged

KW - Netherlands/epidemiology

KW - Pelvic Organ Prolapse/epidemiology

KW - Prevalence

KW - Varicose Veins/epidemiology

U2 - 10.1007/s00192-011-1532-y

DO - 10.1007/s00192-011-1532-y

M3 - Article

C2 - 21811768

SN - 0937-3462

VL - 23

SP - 313

EP - 319

JO - International urogynecology journal

JF - International urogynecology journal

IS - 3

ER -

Pelvic organ prolapse and collagen-associated disorders

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