Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis

Hugo M. Aarts, Nicole D. van Hemert, Timion A. Meijs, Astrid C. van Nieuwkerk, Jurriën M.ten Berg, Joanna J. Wykrzykowska, Niels van Royen, Carl E. Schotborgh, Pim A.L. Tonino, Alexander IJsselmuiden, Tessel N. Vossenberg, Gert K. van Houwelingen, Ton Slagboom, Michiel Voskuil, Ronak Delewi*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)
    64 Downloads (Pure)

    Abstract

    Objective: The importance of revascularisation of significant coronary artery disease (CAD) in patients undergoing transcatheter aortic valve implantation (TAVI) is unclear. Despite the lack of randomised controlled trials comparing different revascularisation strategies, guidelines currently recommend percutaneous coronary intervention (PCI) in patients with significant proximal CAD undergoing TAVI. 

    Methods: In this systematic review and meta-analysis, a systematic search was conducted to identify studies comparing TAVI with and without PCI in patients with significant CAD on pre-TAVI coronary angiography. Endpoints were all-cause mortality, cardiac death, stroke, myocardial infarction and major bleeding. 

    Results: In total, 14 studies were included, involving 3838 patients, of whom 1806 (47%) underwent PCI before TAVI. All-cause mortality did not differ significantly between TAVI with and without preceding PCI at 30 days, 1 year and > 1 year. There were no significant differences in risk of cardiac death, stroke or myocardial infarction between the groups. However, TAVI performed with PCI resulted in a higher risk of major bleeding within 30 days after TAVI (odds ratio: 0.66; 95% confidence interval: 0.46–0.94). 

    Conclusion: This systematic review and meta-analysis showed no significant differences in clinical outcomes between patients with concomitant significant CAD who were treated with TAVI with and without preceding PCI at both short- and long-term follow-up. However, there was a higher risk of major bleeding at 30 days in patients undergoing TAVI with preceding PCI. In the context of serious risk of bias in the included studies, results of randomised controlled trials are warranted.

    Original languageEnglish
    Pages (from-to)489-499
    Number of pages11
    JournalNetherlands Heart Journal
    Volume31
    Issue number12
    DOIs
    Publication statusPublished - Dec-2023

    Keywords

    • Aortic Valve Stenosis
    • Coronary Artery Disease
    • Percutaneous Coronary Intervention
    • Transcatheter Aortic Valve Implantation

    Fingerprint

    Dive into the research topics of 'Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis'. Together they form a unique fingerprint.

    Cite this