Perfect timing: Epigenetic regulation of the circadian clock

Juergen A. Ripperger*, Martha Merrow

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    38 Citations (Scopus)
    191 Downloads (Pure)

    Abstract

    In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of the routes by which phenotype is shaped. Phenotypes that arise without a concomitant mutation of the underlying genome are termed epigenetic phenomena. Here we discuss epigenetic phenomena from histone and DNA modification as it pertains to the dynamic regulatory processes of the circadian clock. Epigenetic phenomena certainly explain some regulatory aspects of the mammalian circadian oscillator. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

    Original languageEnglish
    Pages (from-to)1406-1411
    Number of pages6
    JournalFEBS Letters
    Volume585
    Issue number10
    DOIs
    Publication statusPublished - 20-May-2011

    Keywords

    • Chromatin
    • Methylation
    • Demethylation
    • Hysteresis
    • Histone
    • GENE-EXPRESSION
    • HISTONE H3
    • NUCLEOSOME CORE
    • PROMOTER METHYLATION
    • DNA DEMETHYLATION
    • CHROMATIN FIBER
    • CELL-DIVISION
    • LYSINE 9
    • TRANSCRIPTION
    • REPRESSION

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