Perilymphatic and endolymphatic pressure in the guinea pig after distal dissection of the endolymphatic sac

TJ Warmerdam*, FHHJ Schroder, HP Wit, FWJ Albers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


Hypothesis: The study was designed to investigate whether endolymphatic pressure exceeds perilymphatic pressure in an endolymphatic hydrops model with a partially functioning endolymphatic sac.

Background: Previous investigations of perilymphatic and endolymphatic pressure measurements during endolymphatic hydrops were done in a classic endolymphatic hydrops model. with a surgically blocked endolymphatic duct and sac. This model, in contrast to the clinical situation of Meniere's patients. totally lacks the functional contribution of the endolymphatic sac.

Methods: In the guinea pip, a partially functioning endolymphatic sac was created via dissection of the distal portion of the sac from the sigmoid sinus. Three (n = 5) and 6 months (n = 3) later, perilymphatic and endolymphatic pressures were measured consecutively using a WPI 900A micropressure system.

Results: It was observed that damage to the distal part of the endolymphatic sac caused endolymphatic hydrops in 58% of the casts. The hydrostatic pressure in hydropic ears did not differ from that of control ears. There was no pressure difference between the perilymphatic and endolymphatic compartments in ears with endolymphatic hydrops. The endocochlear potential in ears with hydrops was statistically significantly decreased (p <0.002).

Conclusion: In a hydrops model developed to be more comparable to the histopathologic appearance of Meniere's disease in the inner ear. no hydrostatic pressure difference was measured between the perilymphatic and endolymphatic spaces. The only functional difference from control ears we found was a decreased endocochlear potential.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalOtology & Neurotology
Issue number3
Publication statusPublished - May-2001



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