Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies

A S Ramsteijn, L Van de Wijer, J Rando, J van Luijk, J R Homberg*, J D A Olivier

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)
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Abstract

In the Western world, 2-5% of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) -0.28 [-0.38, -0.18]), more passive stress coping (SMD -0.37 [-0.52, -0.23]), and less efficient sensory processing (SMD -0.37 [-0.69, -0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.

Original languageEnglish
Pages (from-to)53-69
Number of pages17
JournalNeuroscience and Biobehavioral Reviews
Volume114
Early online date19-Apr-2020
DOIs
Publication statusPublished - Jul-2020

Keywords

  • Activity and exploration
  • Animal studies
  • Antidepressants
  • Anxiety
  • Behavior
  • Developmental exposure
  • Ingestive and reward behavior
  • Learning and memory
  • Meta-analysis
  • Motoric behavior
  • Offspring
  • Pregnancy
  • Reflex and pain sensitivity
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Sensory processing
  • Sleep and circadian activity
  • Social behavior
  • Stress coping
  • Systematic review
  • Teratogenic effects
  • DEVELOPMENTAL FLUOXETINE EXPOSURE
  • MATERNAL ANTIDEPRESSANT USE
  • AUTISM SPECTRUM DISORDER
  • DEPRESSIVE-LIKE BEHAVIOR
  • HIPPOCAMPAL BDNF GENE
  • EARLY-LIFE EXPOSURE
  • FORCED SWIM TEST
  • PRENATAL EXPOSURE
  • ADULT MALE
  • SEXUAL-DIFFERENTIATION

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