Peroxisome biogenesis and degradation in yeast: A structure/function analysis

M Veenhuis*, FA Salomons, IJ Van der Klei

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)
324 Downloads (Pure)

Abstract

In yeast, peroxisomes are the site of specific catabolic pathways that characteristically include hydrogen peroxide producing oxidases and catalase. During the last 10 years, much progress has been made in unravelling the molecular mechanisms involved in the biogenesis of this organelle. At present, 23 different genes (PEX genes) have been identified that are involved in different aspects of peroxisome biogenesis (e.g., proliferation, formation of the peroxisomal membrane, import of matrix proteins). The principles of peroxisome degradation are still much less understood. Recently, the first yeast mutants affected in this process have become available and used to clone corresponding genes by functional complementation. In this paper, an overview is presented of the research on yeast peroxisomes, focusing on recent achievements in the molecular aspects of peroxisome development, function, and turnover. (C) 2000 Wiley-Liss. Inc.

Original languageEnglish
Pages (from-to)584-600
Number of pages17
JournalMicroscopy Research and Technique
Volume51
Issue number6
DOIs
Publication statusPublished - 15-Dec-2000

Keywords

  • autophagy
  • microbodies
  • organelles
  • PEX genes
  • protein translocation
  • UBIQUITIN-CONJUGATING ENZYME
  • PROTEIN TRANSLOCATION MACHINERY
  • INTEGRAL MEMBRANE-PROTEIN
  • HANSENULA-POLYMORPHA
  • PICHIA-PASTORIS
  • SACCHAROMYCES-CEREVISIAE
  • TARGETING SIGNAL
  • ALCOHOL OXIDASE
  • PTS1 RECEPTOR
  • MATRIX PROTEIN

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