PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder

Research output: ThesisThesis fully internal (DIV)

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Traumatic brain injury is the leading cause of brain injury in our society with 235 per 100,000 inhabitants per year in the European Union and about 500 per 100,000 inhabitants per year in the United States. About 80% of all these events are accounted for as mild cases. At the same time, whiplash-associated disorder is one of the most frequent consequences of motor vehicle related accidents affecting about 300 per 100,000 inhabitants per year in the United States and Western European countries.
Both brain injuries are frequently underestimated due to their apparent low severity and because in many cases these symptoms disappear within few weeks. Nevertheless, several patients describe long-lasting discomfort in the absence of detectable alterations with conventional clinical diagnostic tools or imaging studies, such as magnetic resonance imaging (MRI) and computed tomography (CT). Therefore, the mechanism behind the long-lasting manifestations remains unknown. It is within this context that functional imaging techniques, such as positron emission tomography (PET) have the potential to provide insight into the undetected changes related to mild traumatic brain injury and whiplash-associated disorder.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
  • Dierckx, Rudi, Supervisor
  • Otte, Andreas, Supervisor, External person
  • Doorduin, Janine, Co-supervisor
Award date2-Dec-2015
Place of Publication[Groningen]
Print ISBNs978-90-367-8314-9
Electronic ISBNs978-90-367-8313-2
Publication statusPublished - 2015


  • PET
  • Mild traumatic brain injury
  • whiplash associated disorder
  • Concussion
  • Whiplash

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