pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Annemarie Broesder; Herman J Woerdenbag; Grietje H Prins; Duong N Nguyen; Henderik W Frijlink; Wouter L J Hinrichs

doi:10.1016/j.drudis.2020.06.011

pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Annemarie Broesder, Herman J Woerdenbag, Grietje H Prins, Duong N Nguyen, Henderik W Frijlink, Wouter L J Hinrichs^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

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Abstract

After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

Original language	English
Pages (from-to)	1362-1373
Number of pages	12
Journal	Drug Discovery Today
Volume	25
Issue number	8
Early online date	15-Jun-2020
DOIs	https://doi.org/10.1016/j.drudis.2020.06.011
Publication status	Published - Aug-2020

Keywords

PHARMACEUTICAL DOSAGE FORMS
SMALL-INTESTINAL TRANSIT
GASTROINTESTINAL TRANSIT
INTRALUMINAL PH
ULCERATIVE-COLITIS
SULFAPYRIDINE APPEARANCE
5-AMINOSALICYLIC ACID
INTRAGASTRIC ACIDITY
RESPONSIVE POLYMERS
GAMMA-SCINTIGRAPHY

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@article{2009a7963eb847fbb61dbf24c43ed38d,

title = "pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems",

abstract = "After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.",

keywords = "PHARMACEUTICAL DOSAGE FORMS, SMALL-INTESTINAL TRANSIT, GASTROINTESTINAL TRANSIT, INTRALUMINAL PH, ULCERATIVE-COLITIS, SULFAPYRIDINE APPEARANCE, 5-AMINOSALICYLIC ACID, INTRAGASTRIC ACIDITY, RESPONSIVE POLYMERS, GAMMA-SCINTIGRAPHY",

author = "Annemarie Broesder and Woerdenbag, {Herman J} and Prins, {Grietje H} and Nguyen, {Duong N} and Frijlink, {Henderik W} and Hinrichs, {Wouter L J}",

year = "2020",

month = aug,

doi = "10.1016/j.drudis.2020.06.011",

language = "English",

volume = "25",

pages = "1362--1373",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "ELSEVIER SCI LTD",

number = "8",

}

TY - JOUR

T1 - pH-dependent ileocolonic drug delivery, part I

T2 - in vitro and clinical evaluation of novel systems

AU - Broesder, Annemarie

AU - Woerdenbag, Herman J

AU - Prins, Grietje H

AU - Nguyen, Duong N

AU - Frijlink, Henderik W

AU - Hinrichs, Wouter L J

PY - 2020/8

Y1 - 2020/8

N2 - After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

AB - After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

KW - PHARMACEUTICAL DOSAGE FORMS

KW - SMALL-INTESTINAL TRANSIT

KW - GASTROINTESTINAL TRANSIT

KW - INTRALUMINAL PH

KW - ULCERATIVE-COLITIS

KW - SULFAPYRIDINE APPEARANCE

KW - 5-AMINOSALICYLIC ACID

KW - INTRAGASTRIC ACIDITY

KW - RESPONSIVE POLYMERS

KW - GAMMA-SCINTIGRAPHY

U2 - 10.1016/j.drudis.2020.06.011

DO - 10.1016/j.drudis.2020.06.011

M3 - Review article

C2 - 32554060

SN - 1359-6446

VL - 25

SP - 1362

EP - 1373

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

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Keywords

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