pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Annemarie Broesder, Herman J Woerdenbag, Grietje H Prins, Duong N Nguyen, Henderik W Frijlink, Wouter L J Hinrichs*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
65 Downloads (Pure)

Abstract

After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

Original languageEnglish
Pages (from-to)1362-1373
Number of pages12
JournalDrug Discovery Today
Volume25
Issue number8
Early online date15-Jun-2020
DOIs
Publication statusPublished - Aug-2020

Keywords

  • PHARMACEUTICAL DOSAGE FORMS
  • SMALL-INTESTINAL TRANSIT
  • GASTROINTESTINAL TRANSIT
  • INTRALUMINAL PH
  • ULCERATIVE-COLITIS
  • SULFAPYRIDINE APPEARANCE
  • 5-AMINOSALICYLIC ACID
  • INTRAGASTRIC ACIDITY
  • RESPONSIVE POLYMERS
  • GAMMA-SCINTIGRAPHY

Cite this