pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients

Annemarie Broesder; Anne-Marijke M A C Kosta; Herman J Woerdenbag; Duong N Nguyen; Henderik W Frijlink; Wouter L J Hinrichs

doi:10.1016/j.drudis.2020.06.012

pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients

Annemarie Broesder, Anne-Marijke M A C Kosta, Herman J Woerdenbag, Duong N Nguyen, Henderik W Frijlink, Wouter L J Hinrichs^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

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Abstract

Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?

Original language	English
Pages (from-to)	1374-1388
Number of pages	15
Journal	Drug Discovery Today
Volume	25
Issue number	8
Early online date	17-Jun-2020
DOIs	https://doi.org/10.1016/j.drudis.2020.06.012
Publication status	Published - Aug-2020

Keywords

GASTRIC RESIDENCE TIME
IN-VIVO EVALUATION
INFLAMMATORY-BOWEL-DISEASE
COLON-TARGETED DELIVERY
GASTROINTESTINAL PH
ULCERATIVE-COLITIS
INTRALUMINAL PH
TRANSIT-TIME
5-AMINOSALICYLIC ACID
BEAGLE DOGS

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pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipientsFinal publisher's version, 961 KBLicence: CC BY

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@article{1d834e844ced4a4baa693f58f4236e2c,

title = "pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients",

abstract = "Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?",

keywords = "GASTRIC RESIDENCE TIME, IN-VIVO EVALUATION, INFLAMMATORY-BOWEL-DISEASE, COLON-TARGETED DELIVERY, GASTROINTESTINAL PH, ULCERATIVE-COLITIS, INTRALUMINAL PH, TRANSIT-TIME, 5-AMINOSALICYLIC ACID, BEAGLE DOGS",

author = "Annemarie Broesder and Kosta, {Anne-Marijke M A C} and Woerdenbag, {Herman J} and Nguyen, {Duong N} and Frijlink, {Henderik W} and Hinrichs, {Wouter L J}",

year = "2020",

month = aug,

doi = "10.1016/j.drudis.2020.06.012",

language = "English",

volume = "25",

pages = "1374--1388",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "ELSEVIER SCI LTD",

number = "8",

}

TY - JOUR

T1 - pH-dependent ileocolonic drug delivery, part II

T2 - Preclinical evaluation of novel drugs and novel excipients

AU - Broesder, Annemarie

AU - Kosta, Anne-Marijke M A C

AU - Woerdenbag, Herman J

AU - Nguyen, Duong N

AU - Frijlink, Henderik W

AU - Hinrichs, Wouter L J

PY - 2020/8

Y1 - 2020/8

N2 - Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?

AB - Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?

KW - GASTRIC RESIDENCE TIME

KW - IN-VIVO EVALUATION

KW - INFLAMMATORY-BOWEL-DISEASE

KW - COLON-TARGETED DELIVERY

KW - GASTROINTESTINAL PH

KW - ULCERATIVE-COLITIS

KW - INTRALUMINAL PH

KW - TRANSIT-TIME

KW - 5-AMINOSALICYLIC ACID

KW - BEAGLE DOGS

U2 - 10.1016/j.drudis.2020.06.012

DO - 10.1016/j.drudis.2020.06.012

M3 - Review article

C2 - 32562842

SN - 1359-6446

VL - 25

SP - 1374

EP - 1388

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients

Abstract

Keywords

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