pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients

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Abstract

Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?

Original languageEnglish
Pages (from-to)1374-1388
Number of pages15
JournalDrug Discovery Today
Volume25
Issue number8
Early online date17-Jun-2020
DOIs
Publication statusPublished - Aug-2020

Keywords

  • GASTRIC RESIDENCE TIME
  • IN-VIVO EVALUATION
  • INFLAMMATORY-BOWEL-DISEASE
  • COLON-TARGETED DELIVERY
  • GASTROINTESTINAL PH
  • ULCERATIVE-COLITIS
  • INTRALUMINAL PH
  • TRANSIT-TIME
  • 5-AMINOSALICYLIC ACID
  • BEAGLE DOGS

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