Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

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Abstract

This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.

Original languageEnglish
Pages (from-to)44-57
Number of pages14
JournalBritish Journal of Anaesthesia
Volume118
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • anesthetics
  • drug interactions
  • pharmacology
  • RESPONSE-SURFACE MODEL
  • TARGET-CONTROLLED INFUSION
  • EFFECT-SITE CONCENTRATION
  • INTRAOPERATIVE PLASMA-CONCENTRATIONS
  • AUDITORY-EVOKED POTENTIALS
  • BISPECTRAL INDEX
  • GENERAL-ANESTHESIA
  • PROTEIN-BINDING
  • PROPOFOL CONCENTRATION
  • SKIN INCISION

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