TY - JOUR
T1 - Pharmacokinetic drug interactions of antimicrobial drugs
T2 - a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and Beta-lactams
AU - Bolhuis, Mathieu S
AU - Panday, Prashant N
AU - Pranger, Arianna D
AU - Kosterink, Jos G W
AU - Alffenaar, Jan-Willem C
PY - 2011
Y1 - 2011
N2 - Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.
AB - Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.
U2 - 10.3390/pharmaceutics3040865
DO - 10.3390/pharmaceutics3040865
M3 - Article
C2 - 24309312
VL - 3
SP - 865
EP - 913
JO - Pharmaceutics
JF - Pharmaceutics
SN - 1999-4923
IS - 4
ER -