Phase I trial with BMS-275183, a novel oral taxane with promising antitumor activity

LE Broker, FYFL de Vos, CJ van Groeningen, BC Kuenen, HE Gall, MH Woo, M Voi, JA Gietema, EGE deVries, G Giaccone*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Abstract

Purpose: BMS-275183 is an orally administered C-4 methyl carbonate analogue of paclitaxel. We did a dose-escalating phase I study to investigate its safety, tolerability, pharmacokinetics, and possible antitumor activity.

Experimental Design: A cycle consisted of four weekly doses of BMS-275183. The starting dose was 5 mg, which was increased by 100% increments (i.e., 5,10, 20 mg/m(2), etc.) in each new cohort consisting of one patient. Cohorts were expanded when toxicity was encountered, and 20 patients were treated at the maximum tolerated dose (MTD). Plasma pharmacokinetics were done on days 1 and 15.

Results: A total of 48 patients were enrolled in this trial. Dose-limiting toxicities consisted of neuropathy, fatigue, diarrhea, and neutropenia. First cycle severe neuropathy was reported in four patients treated at 320 (n = 1), 240 (n = 2), and 160 mg/m(2) (n = 1), whereas eight patients treated at dose levels ranging from 160 to 320 mg/m(2) experienced grade 2 neuropathy in cycle one. The MTD was 200 mg/m(2), as 3 of 20 patients experienced grade 3 or 4 toxicity in cycle one [fatigue (n = 2), and neutropenia/diarrhea (n = 1)]. BMS-275183 was rapidly absorbed with a mean plasma half-life of 22 hours. We observed a significant correlation between drug-exposure and toxicity. Tumor responses were observed in 9 of 38 evaluable patients with non - small cell lung cancer, prostate carcinoma, and other tumor types.

Conclusions: BMS-275183 is generally well tolerated on a weekly schedule. The main toxicity is peripheral neuropathy, and the MTD is 200 mg/m(2). Promising activity was observed in several tumor types, and a phase II trial in non-small cell lung cancer has been initiated.

Original languageEnglish
Pages (from-to)1760-1767
Number of pages8
JournalClinical Cancer Research
Volume12
Issue number6
DOIs
Publication statusPublished - 15-Mar-2006
Event40th Annual Meeting of the American-Society-of-Clinical-Oncology - New Orleans, United States
Duration: 5-Jun-20048-Jun-2004

Keywords

  • METASTATIC BREAST-CANCER
  • PERIPHERAL NEUROPATHY
  • INDUCED NEUROTOXICITY
  • PACLITAXEL TAXOL
  • OVARIAN-CANCER
  • PHARMACOKINETICS
  • DOCETAXEL
  • CHEMOTHERAPY
  • AMIFOSTINE
  • ONCOLOGY

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