Phenotype definition, age, and gender in the genetics of asthma and atopy

RW Bottema; NE Reijmerink; GH Koppelman; M Kerkhof; DS Postma

doi:10.1016/j.iac.2005.07.002

Phenotype definition, age, and gender in the genetics of asthma and atopy

RW Bottema^*, NE Reijmerink, GH Koppelman, M Kerkhof, DS Postma

^*Corresponding author for this work

Groningen Research Institute for Asthma and COPD (GRIAC)

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Asthma and atopy are complex genetic diseases, with gene-gene and gene-environmental interactions determining its clinical expression. It is important to use a clearly described and objective phenotype in studies on the genetics of asthma and atopy. We discuss the modifying effect of age and gender on the associations between genetic variants and the disease phenotype. Future studies should take these two inherent modifiers into account when studying the genetics of asthma in cross-sectional and longitudinal cohort studies.

Original language	English
Pages (from-to)	621-+
Number of pages	20
Journal	Immunology and allergy clinics of north america
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.iac.2005.07.002
Publication status	Published - Nov-2005

Keywords

TOTAL SERUM IGE
SKIN-TEST REACTIVITY
GERMAN MULTICENTER ATOPY
S-TRANSFERASE GSTP1
CORD-BLOOD IGE
1ST 6 YEARS
BRONCHIAL HYPERRESPONSIVENESS
POPULATION-SAMPLE
IMMUNOGLOBULIN-E
GENERAL-POPULATION

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title = "Phenotype definition, age, and gender in the genetics of asthma and atopy",

abstract = "Asthma and atopy are complex genetic diseases, with gene-gene and gene-environmental interactions determining its clinical expression. It is important to use a clearly described and objective phenotype in studies on the genetics of asthma and atopy. We discuss the modifying effect of age and gender on the associations between genetic variants and the disease phenotype. Future studies should take these two inherent modifiers into account when studying the genetics of asthma in cross-sectional and longitudinal cohort studies.",

keywords = "TOTAL SERUM IGE, SKIN-TEST REACTIVITY, GERMAN MULTICENTER ATOPY, S-TRANSFERASE GSTP1, CORD-BLOOD IGE, 1ST 6 YEARS, BRONCHIAL HYPERRESPONSIVENESS, POPULATION-SAMPLE, IMMUNOGLOBULIN-E, GENERAL-POPULATION",

author = "RW Bottema and NE Reijmerink and GH Koppelman and M Kerkhof and DS Postma",

year = "2005",

month = nov,

doi = "10.1016/j.iac.2005.07.002",

language = "English",

volume = "25",

pages = "621--+",

journal = "Immunology and allergy clinics of north america",

issn = "0889-8561",

number = "4",

}

TY - JOUR

T1 - Phenotype definition, age, and gender in the genetics of asthma and atopy

AU - Bottema, RW

AU - Reijmerink, NE

AU - Koppelman, GH

AU - Kerkhof, M

AU - Postma, DS

PY - 2005/11

Y1 - 2005/11

N2 - Asthma and atopy are complex genetic diseases, with gene-gene and gene-environmental interactions determining its clinical expression. It is important to use a clearly described and objective phenotype in studies on the genetics of asthma and atopy. We discuss the modifying effect of age and gender on the associations between genetic variants and the disease phenotype. Future studies should take these two inherent modifiers into account when studying the genetics of asthma in cross-sectional and longitudinal cohort studies.

AB - Asthma and atopy are complex genetic diseases, with gene-gene and gene-environmental interactions determining its clinical expression. It is important to use a clearly described and objective phenotype in studies on the genetics of asthma and atopy. We discuss the modifying effect of age and gender on the associations between genetic variants and the disease phenotype. Future studies should take these two inherent modifiers into account when studying the genetics of asthma in cross-sectional and longitudinal cohort studies.

KW - TOTAL SERUM IGE

KW - SKIN-TEST REACTIVITY

KW - GERMAN MULTICENTER ATOPY

KW - S-TRANSFERASE GSTP1

KW - CORD-BLOOD IGE

KW - 1ST 6 YEARS

KW - BRONCHIAL HYPERRESPONSIVENESS

KW - POPULATION-SAMPLE

KW - IMMUNOGLOBULIN-E

KW - GENERAL-POPULATION

U2 - 10.1016/j.iac.2005.07.002

DO - 10.1016/j.iac.2005.07.002

M3 - Review article

SN - 0889-8561

VL - 25

SP - 621-+

JO - Immunology and allergy clinics of north america

JF - Immunology and allergy clinics of north america

IS - 4

ER -

Phenotype definition, age, and gender in the genetics of asthma and atopy

Abstract

Keywords

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