Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes

Lachlan S. Campbell-Verduyn, Leila Mirfeizi, Rudi A. Dierckx, Philip H. Elsinga*, Ben L. Feringa

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Monodentate phosphoramidite ligands are used to accelerate the copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(I) and Cu(II) salts both function as the copper source in aqueous solution to provide excellent yields.

Original languageEnglish
Pages (from-to)2139-2141
Number of pages3
JournalChemical Communications
Volume40
Issue number16
DOIs
Publication statusPublished - 2009

Keywords

  • 1,3-DIPOLAR CYCLOADDITION
  • TERMINAL ALKYNES
  • CLICK CHEMISTRY
  • CATALYSTS
  • LIGANDS
  • DISCOVERY
  • COPPER(I)
  • COMPLEXES

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