TY - JOUR
T1 - Phosphoramidite-controlled asymmetric hydrogenation with rhodium catalysts
AU - Ager, David J.
AU - de Vries, Andre H. M.
AU - de Vries, Johannes G.
N1 - Cited By (since 1996): 6
PY - 2006/4
Y1 - 2006/4
N2 - Phosphoramidites, and in particular those derived from BINOL, the MonoPhos family of ligands, have proven extremely useful for the asymmetric hydrogenation of carbon-carbon unsaturation using a rhodium catalyst. Many classes of alkenes can be reduced by these catalyst systems. The use of high-throughput experimentation can be applied to the synthesis of MonoPhos ligands and their subsequent screening, in order to find an appropriate candidate for a specific transformation. Suitable mixtures of ligands can also be found by these high-throughput methods.
AB - Phosphoramidites, and in particular those derived from BINOL, the MonoPhos family of ligands, have proven extremely useful for the asymmetric hydrogenation of carbon-carbon unsaturation using a rhodium catalyst. Many classes of alkenes can be reduced by these catalyst systems. The use of high-throughput experimentation can be applied to the synthesis of MonoPhos ligands and their subsequent screening, in order to find an appropriate candidate for a specific transformation. Suitable mixtures of ligands can also be found by these high-throughput methods.
U2 - 10.1595/147106706X111582
DO - 10.1595/147106706X111582
M3 - Article
VL - 50
SP - 54
EP - 63
JO - Platinum Metals Review
JF - Platinum Metals Review
IS - 2
ER -