Phosphoramidite-controlled asymmetric hydrogenation with rhodium catalysts

David J. Ager*, Andre H. M. de Vries, Johannes G. de Vries

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)
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Abstract

Phosphoramidites, and in particular those derived from BINOL, the MonoPhos family of ligands, have proven extremely useful for the asymmetric hydrogenation of carbon-carbon unsaturation using a rhodium catalyst. Many classes of alkenes can be reduced by these catalyst systems. The use of high-throughput experimentation can be applied to the synthesis of MonoPhos ligands and their subsequent screening, in order to find an appropriate candidate for a specific transformation. Suitable mixtures of ligands can also be found by these high-throughput methods.

Original languageEnglish
Pages (from-to)54-63
Number of pages10
JournalPlatinum Metals Review
Volume50
Issue number2
DOIs
Publication statusPublished - Apr-2006

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