Phosphoregulation of the autophagy machinery by kinases and phosphatases

Mariya Licheva, Babu Raman, Claudine Kraft, Fulvio Reggiori*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)
121 Downloads (Pure)

Abstract

Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate the function and properties of protein networks within various cellular processes. For example, the process of autophagy strongly depends on the balanced action of kinases and phosphatases. Highly conserved from the budding yeast Saccharomyces cerevisiae to humans, autophagy is a tightly regulated self-degradation process that is crucial for survival, stress adaptation, maintenance of cellular and organismal homeostasis, and cell differentiation and development. Many studies have emphasized the importance of kinases and phosphatases in the regulation of autophagy and identified many of the core autophagy proteins as their direct targets. In this review, we summarize the current knowledge on kinases and phosphatases acting on the core autophagy machinery and discuss the relevance of phosphoregulation for the overall process of autophagy.

Original languageEnglish
Pages (from-to)104-123
Number of pages20
JournalAutophagy
Volume18
Issue number1
DOIs
Publication statusPublished - 2022

Keywords

  • Autophagosome
  • macroautophagy
  • PAS
  • phagophore
  • posttranslational modification

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