Photo-Biocatalysis: Biotransformations in the Presence of Light

Luca Schmermund, Valentina Jurkas, F. Feyza Oezgen, Giovanni D. Barone, Hanna C. Buechsenschuetz, Christoph K. Winkler, Sandy Schmidt, Robert Kourist, Wolfgang Kroutil

Research output: Contribution to journalReview articleAcademicpeer-review

60 Citations (Scopus)
26 Downloads (Pure)

Abstract

Light has received increased attention for various chemical reactions but also in combination with biocatalytic reactions. Because currently only a few enzymatic reactions are known, which per se require light, most transformations involving light and a biocatalyst exploit light either for providing the cosubstrate or cofactor in an appropriate redox state for the biotransformation. In selected cases, a promiscuous activity of known enzymes in the presence of light could be induced. In other approaches, light induced chemical reactions have been combined with a biocatalytic step, or light-induced biocatalytic reactions were combined with chemical reactions in a linear cascade. Finally, enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction. This Review gives an overview of the various approaches for using light in biocatalysis.

Original languageEnglish
Pages (from-to)4115-4144
Number of pages59
JournalACS Catalysis
Volume9
Issue number5
DOIs
Publication statusPublished - May-2019
Externally publishedYes

Keywords

  • photocatalysis
  • biocatalysis
  • biotransformation
  • cascades
  • cofactor recycling
  • NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE
  • VISIBLE-LIGHT
  • PHOTOSYSTEM-II
  • ASYMMETRIC REDUCTION
  • WATER OXIDATION
  • ENZYME-ACTIVITY
  • OPTICAL CONTROL
  • IN-VIVO
  • COMBINING PHOTOCATALYSIS
  • NICOTINAMIDE COFACTORS

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