Photo-induced processes within noncovalent complexes involved in molecular recognition

M. Abdelmouleh, Mathieu Lalande, Violaine Vizcaino, Thomas Schlathölter, Jean-Christophe Poully*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Investigating the intrinsic properties of molecular complexes is crucial for understanding the influence of noncovalent interactions on fundamental chemical reactions. Moreover, specific molecular recognition between a ligand and its receptor is a highly important biological process, but little is known about the effects of ionizing radiation on ligand–receptor complexes. The processes triggered by VUV photoabsorption on isolated noncovalent complexes between the glycopeptide antibiotic vancomycin and a mimic of its receptor have been probed by means of mass spectrometry and synchrotron radiation. In the case of protonated species, the glycosidic bond of vancomycin was cleaved with low activation energy, regardless of the molecular environment. In sharp contrast, for deprotonated species, electron photodetachment from carboxylate groups only triggered CO2 loss, whereas the glycosidic bond remained intact. Importantly, the noncovalent complex was also found to survive VUV photoabsorption only when the native structure is conserved in the gas phase.

Original languageEnglish
Pages (from-to) 2243-2250
Number of pages8
JournalChemistry - A European Journal
Volume26
Issue number10
Early online date2-Dec-2019
DOIs
Publication statusPublished - 20-Feb-2020

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