Photopharmacology: Beyond Proof of Principle

Willem A. Velema, Wiktor Szymanski*, Bernard Feringa

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

686 Citations (Scopus)
1855 Downloads (Pure)

Abstract

Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space. Photopharmacology aims at solving this issue by incorporating photoswitchable groups into the molecular structure of bioactive compounds. These switching units allow for the use of light as an external control element for pharmacological activity, which can be delivered with very high spatiotemporal precision. This Perspective presents the reader with the current state and outlook on photopharmacology. In particular, the principles behind photoregulation of bioactivity, the challenges of molecular design, and the possible therapeutic scenarios are discussed.

Original languageEnglish
Pages (from-to)2178-2191
Number of pages14
JournalJournal of the American Chemical Society
Volume136
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • ADVERSE DRUG-REACTIONS
  • CARBONIC-ANHYDRASE-I
  • PHOTODYNAMIC THERAPY
  • OPTICAL CONTROL
  • AZOBENZENE PHOTOSWITCHES
  • SUBSTITUTED AZOBENZENES
  • CONFORMATIONAL STATES
  • PHOTOCHEMICAL CONTROL
  • MOLECULAR-MECHANISMS
  • TRANS ISOMERIZATION

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