Photoswitchable architecture transformation of a DNA-hybrid assembly at the microscopic and macroscopic scale

Nadja A Simeth, Paula de Mendoza, Victor R A Dubach, Marc C A Stuart, Julien W Smith, Tibor Kudernac, Wesley R Browne, Ben L Feringa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
49 Downloads (Pure)

Abstract

Molecular recognition-driven self-assembly employing single-stranded DNA (ssDNA) as a template is a promising approach to access complex architectures from simple building blocks. Oligonucleotide-based nanotechnology and soft-materials benefit from the high information storage density, self-correction, and memory function of DNA. Here we control these beneficial properties with light in a photoresponsive biohybrid hydrogel, adding an extra level of function to the system. An ssDNA template was combined with a complementary photo-responsive unit to reversibly switch between various functional states of the supramolecular assembly using a combination of light and heat. We studied the structural response of the hydrogel at both the microscopic and macroscopic scale using a combination of UV-vis absorption and CD spectroscopy, as well as fluorescence, transmission electron, and atomic force microscopy. The hydrogels grown from these supramolecular self-assembly systems show remarkable shape-memory properties and imprinting shape-behavior while the macroscopic shape of the materials obtained can be further manipulated by irradiation.

Original languageEnglish
Pages (from-to)3263-3272
Number of pages10
JournalChemical Science
Volume13
Issue number11
DOIs
Publication statusPublished - 2-Mar-2022

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