Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon

Saskia Corine van de Zande; Karin Eijkelenkamp; Amaal Eman Abdulle; Andries Jan Smit; Johannes Zwerver; Inge van den Akker-Scheek; Douwe Johannes Mulder

doi:10.1007/s10067-025-07416-w

Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon

Saskia Corine van de Zande^*, Karin Eijkelenkamp, Amaal Eman Abdulle, Andries Jan Smit, Johannes Zwerver, Inge van den Akker-Scheek, Douwe Johannes Mulder

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

INTRODUCTION: Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.

OBJECTIVE: This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).

METHODS: A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.

RESULTS: Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74%) with RP complied to health enhancing PA guidelines (70% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).

CONCLUSION: Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.

Original language	English
Pages (from-to)	2101-2107
Number of pages	7
Journal	Clinical Rheumatology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1007/s10067-025-07416-w
Publication status	Published - Jun-2025

Keywords

Humans
Female
Quality of Life
Sedentary Behavior
Exercise
Middle Aged
Adult
Raynaud Disease/psychology
Surveys and Questionnaires
Aged
Stress, Psychological
Cohort Studies

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@article{c041f6a750d94a88b9e9c48d1d645201,

title = "Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon",

abstract = "INTRODUCTION: Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.OBJECTIVE: This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).METHODS: A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.RESULTS: Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74\%) with RP complied to health enhancing PA guidelines (70\% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).CONCLUSION: Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75\% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.",

keywords = "Humans, Female, Quality of Life, Sedentary Behavior, Exercise, Middle Aged, Adult, Raynaud Disease/psychology, Surveys and Questionnaires, Aged, Stress, Psychological, Cohort Studies",

author = "\{van de Zande\}, \{Saskia Corine\} and Karin Eijkelenkamp and \{Eman Abdulle\}, Amaal and Smit, \{Andries Jan\} and Johannes Zwerver and \{van den Akker-Scheek\}, Inge and Mulder, \{Douwe Johannes\}",

note = "{\textcopyright} 2025. The Author(s).",

year = "2025",

month = jun,

doi = "10.1007/s10067-025-07416-w",

language = "English",

volume = "44",

pages = "2101--2107",

journal = "Clinical Rheumatology",

issn = "0770-3198",

publisher = "Springer",

number = "6",

}

TY - JOUR

T1 - Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon

AU - van de Zande, Saskia Corine

AU - Eijkelenkamp, Karin

AU - Eman Abdulle, Amaal

AU - Smit, Andries Jan

AU - Zwerver, Johannes

AU - van den Akker-Scheek, Inge

AU - Mulder, Douwe Johannes

PY - 2025/6

Y1 - 2025/6

N2 - INTRODUCTION: Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.OBJECTIVE: This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).METHODS: A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.RESULTS: Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74%) with RP complied to health enhancing PA guidelines (70% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).CONCLUSION: Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.

AB - INTRODUCTION: Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.OBJECTIVE: This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).METHODS: A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.RESULTS: Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74%) with RP complied to health enhancing PA guidelines (70% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).CONCLUSION: Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.

KW - Humans

KW - Female

KW - Quality of Life

KW - Sedentary Behavior

KW - Exercise

KW - Middle Aged

KW - Adult

KW - Raynaud Disease/psychology

KW - Surveys and Questionnaires

KW - Aged

KW - Stress, Psychological

KW - Cohort Studies

U2 - 10.1007/s10067-025-07416-w

DO - 10.1007/s10067-025-07416-w

M3 - Article

C2 - 40244470

SN - 0770-3198

VL - 44

SP - 2101

EP - 2107

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 6

ER -

Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon

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