Placebo-controlled trial of house dust mite-impermeable mattress covers - Effect on symptoms in early childhood

LP Koopman, RT van Strien, M Kerkhof, A Wijga, HA Smit, JC de Jongste, J Gerritsen, RC Aalberse, B Brunekreef, HJ Neijens*, Prevention Incidence Asthma Mite

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

123 Citations (Scopus)

Abstract

We investigated the effect of house dust mite (HDM)-allergen avoidance on the development of respiratory Symptoms, atopic dermatitis, and atopic sensitization by performing a double blind, placebo-controlled trial. In total, 1,282 allergic pregnant women were selected (416 received HDM allergen-impermeable mattress covers for the parents' and child's mattress in the third trimester of pregnancy [active], 394 received placebo covers, 472 received no intervention). Data on allergen exposure, clinical symptoms, and immunoglobulin E were collected prospectively. The prevalence of night cough without a cold in the second year of life was lower in the group with active covers compared with the group with placebo covers (adjusted odds ratio 0.65; 95% confidence interval 0.4-1.0). No effect of the intervention was seen on other respiratory symptoms, atopic dermatitis, and total and specific immunoglobulin E. It can be concluded that application of HDM-impermeable mattress covers on the child's and parents' beds reduced night cough, but not other respiratory symptoms, atopic dermatitis, and atopic sensitization in the first 2 years of life. Follow-up will determine the long-term effect of the intervention on the development of atopic disease.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume166
Issue number3
DOIs
Publication statusPublished - 1-Aug-2002

Keywords

  • mite control
  • wheezing
  • asthma
  • atopy
  • allergens
  • DER-P-I
  • RESPIRATORY SYMPTOMS
  • ALLERGEN EXPOSURE
  • EARLY-LIFE
  • HIGH-RISK
  • ASTHMA
  • INFANTS
  • IGE
  • SENSITIZATION
  • SENSITIVITY

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