PLACENTAL-LIKE ALKALINE-PHOSPHATASE AND DNA FLOW-CYTOMETRY IN SPERMATOCYTIC SEMINOMA

[No Value] DEKKER, T ROZEBOOM, J DELEMARRE, JW OOSTERHUIS, A. Dam

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    Abstract

    Immunohistochemical analysis was done on 7 testicular tumors classified as spermatocytic seminoma (SS) and 25 classic seminomas. Except for a few scattered cells, the spermatocytic seminomas were negative for placental-like alkaline phosphatase (PLAP); the classic seminomas were all positive for this enzyme. The SS also were negative for alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (hCG), and leukocyte common antigen (LCA). The ploidy of the seven tumors of SS was as follows: two, diploid; two, near-diploid; one, tetraploid; one, aneuploid; and one, uninterpretable. The essentially negative staining of SS for PLAP was strikingly different from the pattern in classic seminoma. Thus, staining for this enzyme is useful for making the differential diagnosis between classic seminoma and SS. To differentiate between malignant lymphoma and SS, staining for leukocyte common antigen is helpful.

    Original languageEnglish
    Pages (from-to)993-996
    Number of pages4
    JournalCancer
    Volume69
    Issue number4
    Publication statusPublished - 15-Feb-1992

    Keywords

    • GERM-CELL TUMORS
    • CARCINOMA-INSITU
    • TESTIS
    • PRECURSOR

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