Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

Robin P. F. Dullaart; Peter Plomgaard; Rindert de Vries; Bjorn Dahlback; Lars B. Nielsen

doi:10.1016/j.cca.2009.06.010

Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

Robin P. F. Dullaart^*, Peter Plomgaard, Rindert de Vries, Bjorn Dahlback, Lars B. Nielsen

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM.

Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined.

Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p0.20). Age- and sex adjusted IMT was lower in subjects with MetS (p

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Clinica chimica acta
Volume	406
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cca.2009.06.010
Publication status	Published - 11-Aug-2009

Keywords

Apolipoprotein M
Intima media thickness
Leptin
Metabolic syndrome
DENSITY-LIPOPROTEIN METABOLISM
REVERSE CHOLESTEROL TRANSPORT
TYPE-2 DIABETES-MELLITUS
EXPRESSION IN-VIVO
C-REACTIVE PROTEIN
INSULIN-RESISTANCE
SUBCLINICAL ATHEROSCLEROSIS
CAROTID-ARTERY
LEPTIN
ADULTS

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title = "Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness",

abstract = "Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM.Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined.Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p0.20). Age- and sex adjusted IMT was lower in subjects with MetS (pConclusions: Plasma apoM is reduced in MetS. In this study, apoM did not predict subclinical atherosclerosis. (C) 2009 Elsevier B.V. All rights reserved.",

keywords = "Apolipoprotein M, Intima media thickness, Leptin, Metabolic syndrome, DENSITY-LIPOPROTEIN METABOLISM, REVERSE CHOLESTEROL TRANSPORT, TYPE-2 DIABETES-MELLITUS, EXPRESSION IN-VIVO, C-REACTIVE PROTEIN, INSULIN-RESISTANCE, SUBCLINICAL ATHEROSCLEROSIS, CAROTID-ARTERY, LEPTIN, ADULTS",

author = "Dullaart, {Robin P. F.} and Peter Plomgaard and {de Vries}, Rindert and Bjorn Dahlback and Nielsen, {Lars B.}",

year = "2009",

month = aug,

day = "11",

doi = "10.1016/j.cca.2009.06.010",

language = "English",

volume = "406",

pages = "129--133",

journal = "Clinica chimica acta",

issn = "0009-8981",

publisher = "ELSEVIER SCIENCE BV",

number = "1-2",

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TY - JOUR

T1 - Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

AU - Dullaart, Robin P. F.

AU - Plomgaard, Peter

AU - de Vries, Rindert

AU - Dahlback, Bjorn

AU - Nielsen, Lars B.

PY - 2009/8/11

Y1 - 2009/8/11

N2 - Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM.Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined.Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p0.20). Age- and sex adjusted IMT was lower in subjects with MetS (pConclusions: Plasma apoM is reduced in MetS. In this study, apoM did not predict subclinical atherosclerosis. (C) 2009 Elsevier B.V. All rights reserved.

AB - Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM.Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined.Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p0.20). Age- and sex adjusted IMT was lower in subjects with MetS (pConclusions: Plasma apoM is reduced in MetS. In this study, apoM did not predict subclinical atherosclerosis. (C) 2009 Elsevier B.V. All rights reserved.

KW - Apolipoprotein M

KW - Intima media thickness

KW - Leptin

KW - Metabolic syndrome

KW - DENSITY-LIPOPROTEIN METABOLISM

KW - REVERSE CHOLESTEROL TRANSPORT

KW - TYPE-2 DIABETES-MELLITUS

KW - EXPRESSION IN-VIVO

KW - C-REACTIVE PROTEIN

KW - INSULIN-RESISTANCE

KW - SUBCLINICAL ATHEROSCLEROSIS

KW - CAROTID-ARTERY

KW - LEPTIN

KW - ADULTS

U2 - 10.1016/j.cca.2009.06.010

DO - 10.1016/j.cca.2009.06.010

M3 - Article

SN - 0009-8981

VL - 406

SP - 129

EP - 133

JO - Clinica chimica acta

JF - Clinica chimica acta

IS - 1-2

ER -

Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

Abstract

Keywords

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