Plasma copeptin and chronic kidney disease risk in 3 European cohorts from the general population

Ray El Boustany, Irina Tasevska, Esther Meijer, Lyanne M Kieneker, Sofia Enhörning, Guillaume Lefèvre, Kamel Mohammedi, Michel Marre, Frédéric Fumeron, Beverley Balkau, Nadine Bouby, Lise Bankir, Stephan Jl Bakker, Ronan Roussel, Olle Melander, Ron T Gansevoort, Gilberto Velho*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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BACKGROUND. The prevalence of chronic kidney disease (CKD) is increasing worldwide. The identification of factors contributing to its progression is important for designing preventive measures. Previous studies have suggested that chronically high vasopressin is deleterious to renal function. Here, we evaluated the association of plasma copeptin, a surrogate of vasopressin, with the incidence of CKD in the general population.

METHODS. We studied 3 European cohorts: DESIR (n = 5,047; France), MDCS-CC (n = 3,643; Sweden), and PREVEND (n = 7,684; the Netherlands). Median follow-up was 8.5, 16.5, and 11.3 years, respectively. Pooled data were analyzed at an individual level for 4 endpoints during follow-up: incidence of stage 3 CKD (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m(2)); the KDIGO criterion "certain drop in eGFR"; rapid kidney function decline (eGFR slope steeper than -3 ml/min/1.73 m(2)/yr); and incidence of microalbuminuria.

RESULTS. The upper tertile of plasma copeptin was significantly and independently associated with a 49% higher risk for stage 3 CKD (P <0.0001); a 64% higher risk for kidney function decline, as defined by the KDIGO criterion (P <0.0001); a 79% higher risk for rapid kidney function decline (P <0.0001); and a 24% higher risk for microalbuminuria (P = 0.008).

CONCLUSIONS. High copeptin levels are associated with the development and the progression of CKD in the general population. Intervention studies are needed to assess the potential beneficial effect on kidney health in the general population of reducing vasopressin secretion or action.

Original languageEnglish
Article number121479
Number of pages11
JournalJCI Insight
Issue number13
Early online date12-Jul-2018
Publication statusPublished - 12-Jul-2018


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