Plasma creatine and incident type 2 diabetes in a general population-based cohort: The PREVEND study

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Abstract

Background: Type 2 diabetes is associated with both impaired insulin action at target tissues and impaired insulin secretion in pancreatic beta cells. Mitochondrial dysfunction may play a role in both insulin resistance and impaired insulin secretion. Plasma creatine has been proposed as a potential marker for mitochondrial dysfunction. We aimed to investigate the association between plasma creatine and incident type 2 diabetes.

Methods: We measured fasting plasma creatine concentrations by nuclear magnetic resonance spectroscopy in participants of the general population-based PREVEND study. The study outcome was incident type 2 diabetes, defined as a fasting plasma glucose >= 7.0 mmol/L (126 mg/dl); a random sample plasma glucose >= 11.1 mmol/L (200 mg/dl); self-report of a physician diagnosis or the use of glucose-lowering medications based on a central pharmacy registration. Associations of plasma creatine with type 2 diabetes were quantified using Cox proportional hazards models and were adjusted for potential confounders.

Results: We included 4735 participants aged 52 +/- 11 years, of whom 49% were male. Mean plasma creatine concentrations were 36.7 +/- 17.6 mu mol/L, with lower concentrations in males than in females (30.4 +/- 15.1 mu mol/L vs. 42.7 +/- 17.7 mu mol/L; p for difference

Conclusion: Fasting plasma creatine concentrations are lower in males than in females. Higher plasma creatine is associated with an increased risk of type 2 diabetes in males.

Original languageEnglish
Number of pages12
JournalClinical Endocrinology
Early online date21-Dec-2020
DOIs
Publication statusPublished - 10-Jan-2021

Keywords

  • creatine
  • general population
  • type 2 diabetes
  • ACTIVATED PROTEIN-KINASE
  • KIDNEY L-ARGININE
  • MITOCHONDRIAL DYSFUNCTION
  • GLYCINE AMIDINOTRANSFERASE
  • TRANSPORTER
  • MUSCLE
  • DEFICIENCY
  • MECHANISMS
  • REPRESSION
  • LEUKOCYTES

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