Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease

Monica L. Bertoia*, Jennifer K. Pai, John P. Cooke, Michel M. Joosten, Murray A. Mittleman, Eric B. Rimm, Kenneth J. Mukamal

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    29 Citations (Scopus)

    Abstract

    Objective: Few studies have examined the roles of homocysteine and related nutrients in the development of peripheral artery disease (PAD). We examined the associations between plasma homocysteine, dietary B vitamins, betaine, choline, and supplemental folic acid use and incidence of PAD.

    Methods: We used two cohort studies of 72,348 women in the Nurses' Health Study (NHS, 1990-2010) and 44,504 men in the Health Professionals Follow-up Study (HPFS, 1986-2010). We measured plasma homocysteine in nested matched case-control studies of clinically recognized PAD within both cohorts, including 143 PAD cases and 424 controls within the NHS (1990-2010) and 143 PAD cases and 428 controls within the HPFS (1994-2008). We examined the association between diet and risk of incident PAD in the cohorts using a food frequency questionnaire and 790 cases of PAD over 3.1 million person-years of follow-up.

    Results: Higher homocysteine levels were positively associated with risk of PAD in men (adjusted IRR 2.17; 95% CI, 1.08-4.38 for tertile 3 vs. 1). There was no evidence of an association in women (adjusted IRR 1.14; 95% CI, 0.61-2.12). Similarly, higher folate intake, including supplements, was inversely associated with risk of PAD in men (adjusted HR 0.90; 95% CI, 0.82-0.98 for each 250 mu g increase) but not women (HR 1.01, 95% CI, 0.88-1.15). Intakes of the other B vitamins, betaine, and choline were not consistently associated with risk of PAD in men or women.

    Conclusion: Homocysteine levels were positively associated and dietary folate intake was inversely associated with risk of PAD in men but not in women. (C) 2014 Published by Elsevier Ireland Ltd.

    Original languageEnglish
    Pages (from-to)94-101
    Number of pages8
    JournalATHEROSCLEROSIS
    Volume235
    Issue number1
    DOIs
    Publication statusPublished - Jul-2014

    Keywords

    • Peripheral artery disease
    • Homocysteine
    • Folate
    • Vitamin B12
    • Vitamin B6
    • Riboflavin
    • Betaine
    • Choline
    • PHYSICAL-ACTIVITY QUESTIONNAIRE
    • FOLIC-ACID SUPPLEMENTATION
    • MALE HEALTH-PROFESSIONALS
    • CORONARY-HEART-DISEASE
    • CARDIOVASCULAR-DISEASE
    • MYOCARDIAL-INFARCTION
    • SERUM FOLATE
    • RIBOFLAVIN SUPPLEMENTATION
    • POSTMENOPAUSAL WOMEN
    • ENDOTHELIAL FUNCTION

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