Plasma IL-8 and IL-6 levels can be used to define a group with low risk of septicaemia among cancer patients with fever and neutropenia

ESJM de Bont*, E Vellenga, JCJM Swaanenburg, [No Value] Fidler, PJ Visser-van Brummen, WA Kamps

*Corresponding author for this work

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Abstract

The standard therapy for patients with fever and chemotherapy-related neutropenia is hospitalization and infusion of broad-spectrum antibiotics. Early discharge of a defined group of patients at low risk for septicaemia would be of great advantage for these patients. Ih this study plasma interleukin-8 (IL-8) and interleukin-6 (IL-6) levels measured at start of fever (n = 72) could define a low-risk group of febrile patients with neutropenia due to chemotherapy. For this purpose we collected and analysed data on 72 fever episodes from 53 patients with chemotherapy-related neutropenia, aged between 1 and 66 years. Of the 72 episodes, 18 were classified as bacteraemia and/or clinical sepsis (sepsis group), The IL-6 and IL-8 plasma concentration were significantly increased in patients with chemotherapy-related neutropenia and fever due to bacteraemia versus fever of non-bacterial origin (P = 0.043 and P = 0.022 respectively). Logistic regression analysis, with sepsis as the outcome variable, revealed significant effects of age combined with either IL-6 or IL-8. Sepsis occurrence was lowest for patients

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalBritish Journal of Haematology
Volume107
Issue number2
Publication statusPublished - Nov-1999

Keywords

  • fever
  • chemotherapy-induced neutropenia
  • CRP
  • IL-6
  • IL-8
  • C-REACTIVE PROTEIN
  • TUMOR-NECROSIS-FACTOR
  • EARLY HOSPITAL DISCHARGE
  • FEBRILE NEUTROPENIA
  • PROLONGED NEUTROPENIA
  • SERUM CONCENTRATIONS
  • NEONATAL SEPSIS
  • FACTOR-ALPHA
  • INTERLEUKIN-6
  • CHILDREN

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