Plasma lipid peroxidation and progression of disability in multiple sclerosis

M. Koch*, J. Mostert, A. V. Arutjunyan, M. Stepanov, A. Teelken, D. Heersema, J. De Keyser

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    55 Citations (Scopus)

    Abstract

    Oxidative stress has been implicated in the pathophysiology of multiple sclerosis (MS), but its relation to disease progression is uncertain. To evaluate the relationship of plasma lipid peroxidation with progression of disability in MS, we measured blood plasma fluorescent lipid peroxidation products (PFLPP) levels in 23 patients with RRMS with a benign course, 32 with secondary progressive MS, 24 with primary progressive MS and 30 healthy controls. None of the patients had a relapse within the previous 3 months. Progression of disability was evaluated during a follow-up period of 5 years by the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score (MSSS). We found plasma PFLPP levels elevated in patients with MS compared with controls (P <0.0001), but there was no difference between patients with a benign and progressive disease course. There was no correlation between PFLPP levels and worsening of disability on the EDSS and speed of progression on the MSSS. Our data suggest that there is no relation between the degree of oxidative stress in plasma and progression of disability in MS.

    Original languageEnglish
    Pages (from-to)529-533
    Number of pages5
    JournalEuropean Journal of Neurology
    Volume14
    Issue number5
    DOIs
    Publication statusPublished - May-2007

    Keywords

    • multiple sclerosis
    • oxidative stress
    • prognosis
    • progression
    • OXIDATIVE STRESS
    • CEREBROSPINAL-FLUID
    • NATURAL-HISTORY
    • PRODUCTS
    • DISEASE
    • THERAPY
    • TISSUES
    • BLOOD
    • SERUM

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