Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients

WiN Study Grp, Maurice Swinkels, Ferdows Atiq, Petra E. Burgisser, Iris van Moort, Karina Meijer, Jeroen Eikenboom, Karin Fijnvandraat, Karin P. M. van Galen, Joke de Meris, Saskia E. M. Schols, Johanna G. van der Bom, Marjon H. Cnossen, Jan Voorberg, Frank W. G. Leebeek, Ruben Bierings, A. J. Gerard Jansen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in type 2B and current bleeding phenotype was significantly associated with higher PF4 levels, particularly in type 1 VWD. Based on our findings we speculate that platelet degranulation and cargo release may play a role across VWD subtypes.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalBritish Journal of Haematology
Volume197
Issue number4
DOIs
Publication statusPublished - May-2022

Keywords

  • bleeding disorders
  • platelet activation
  • platelet factor 4
  • VWD
  • VWF

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