Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

Ton Lisman

doi:10.1007/s00441-017-2727-4

Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

Ton Lisman^*

^*Corresponding author for this work

Groningen Institute for Organ Transplantation (GIOT)

Research output: Contribution to journal › Review article › peer-review

140 Citations (Scopus)

348 Downloads (Pure)

Abstract

Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.

Original language	English
Pages (from-to)	567-576
Number of pages	10
Journal	Cell and Tissue Research
Volume	371
Issue number	3
DOIs	https://doi.org/10.1007/s00441-017-2727-4
Publication status	Published - Mar-2018

Keywords

Platelet
Neutrophil
Inflammation
Thrombosis
Ischemia
ISCHEMIA-REPERFUSION INJURY
VON-WILLEBRAND-FACTOR
DEEP-VEIN THROMBOSIS
MURINE ACETAMINOPHEN HEPATOTOXICITY
PROTEASE-ACTIVATED RECEPTOR-4
EXTRACELLULAR TRAP FORMATION
TISSUE FACTOR EXPRESSION
ACUTE CORONARY SYNDROME
IMPAIRS HOST-DEFENSE
INDUCED LIVER-INJURY

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10.1007/s00441-017-2727-4Licence: CC BY

Platelet–neutrophil interactions as drivers of inflammatory and thrombotic diseaseFinal publisher's version, 629 KBLicence: CC BY

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Cite this

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title = "Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease",

abstract = "Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.",

keywords = "Platelet, Neutrophil, Inflammation, Thrombosis, Ischemia, ISCHEMIA-REPERFUSION INJURY, VON-WILLEBRAND-FACTOR, DEEP-VEIN THROMBOSIS, MURINE ACETAMINOPHEN HEPATOTOXICITY, PROTEASE-ACTIVATED RECEPTOR-4, EXTRACELLULAR TRAP FORMATION, TISSUE FACTOR EXPRESSION, ACUTE CORONARY SYNDROME, IMPAIRS HOST-DEFENSE, INDUCED LIVER-INJURY",

author = "Ton Lisman",

year = "2018",

month = mar,

doi = "10.1007/s00441-017-2727-4",

language = "English",

volume = "371",

pages = "567--576",

journal = "Cell and Tissue Research",

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TY - JOUR

T1 - Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

AU - Lisman, Ton

PY - 2018/3

Y1 - 2018/3

N2 - Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.

AB - Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.

KW - Platelet

KW - Neutrophil

KW - Inflammation

KW - Thrombosis

KW - Ischemia

KW - ISCHEMIA-REPERFUSION INJURY

KW - VON-WILLEBRAND-FACTOR

KW - DEEP-VEIN THROMBOSIS

KW - MURINE ACETAMINOPHEN HEPATOTOXICITY

KW - PROTEASE-ACTIVATED RECEPTOR-4

KW - EXTRACELLULAR TRAP FORMATION

KW - TISSUE FACTOR EXPRESSION

KW - ACUTE CORONARY SYNDROME

KW - IMPAIRS HOST-DEFENSE

KW - INDUCED LIVER-INJURY

U2 - 10.1007/s00441-017-2727-4

DO - 10.1007/s00441-017-2727-4

M3 - Review article

SN - 0302-766X

VL - 371

SP - 567

EP - 576

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 3

ER -