Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

Ton Lisman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)
345 Downloads (Pure)

Abstract

Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.

Original languageEnglish
Pages (from-to)567-576
Number of pages10
JournalCell and Tissue Research
Volume371
Issue number3
DOIs
Publication statusPublished - Mar-2018

Keywords

  • Platelet
  • Neutrophil
  • Inflammation
  • Thrombosis
  • Ischemia
  • ISCHEMIA-REPERFUSION INJURY
  • VON-WILLEBRAND-FACTOR
  • DEEP-VEIN THROMBOSIS
  • MURINE ACETAMINOPHEN HEPATOTOXICITY
  • PROTEASE-ACTIVATED RECEPTOR-4
  • EXTRACELLULAR TRAP FORMATION
  • TISSUE FACTOR EXPRESSION
  • ACUTE CORONARY SYNDROME
  • IMPAIRS HOST-DEFENSE
  • INDUCED LIVER-INJURY

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