Abstract
The enzymatic hydrolyses of a variety of alpha-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various alpha-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for alpha-substituted lactic esters. We observed that the enantioselectivity of PLE depends strongly on the length and nature of the substituent at the alpha-position. Some consequences for an active site model of PLE are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 705-720 |
| Number of pages | 16 |
| Journal | Tetrahedron-Asymmetry |
| Volume | 2 |
| Issue number | 7 |
| Publication status | Published - 1991 |
Keywords
- PIG-LIVER ESTERASE
- ORGANIC-SYNTHESIS
- ACID-ESTERS
- ENANTIOSELECTIVE HYDROLYSIS
- ASYMMETRIC-SYNTHESIS
- ENZYMES
- RESOLUTION