Poly(DL-lactide-epsilon-caprolactone) nerve guides perform better than autologous nerve grafts

WFA DenDunnen, B VanderLei, JM Schakenraad, [No Value] Stokroos, E Blaauw, AJ Pennings, PH Robinson, H. Bartels

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Abstract

The aim of this study was to compare the speed and quality of nerve regeneration after reconstruction using a biodegradable nerve guide or an autologous nerve graft. We evaluated nerve regeneration using light microscopy, transmission electron microscopy and morphometric analysis. Nerve regeneration across a short nerve gap, after reconstruction using a biodegradable nerve guide, is faster and qualitatively better, when compared with nerve reconstruction using an autologous nerve graft. Therefore, we conclude that in the case of a short nerve gap (1 cm), reconstruction should be carried out using a biodegradable nerve guide constructed of a copolymer of DL-lactide and epsilon-caprolactone. (C) 1997 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)348-357
Number of pages10
JournalMicrosurgery
Volume17
Issue number7
Publication statusPublished - 1996

Keywords

  • PERIPHERAL-NERVE
  • EXPERIMENTAL-MODEL
  • REGENERATION
  • REPAIR
  • GROWTH
  • TUBE
  • RAT
  • GAP

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