Polygenic risk for aggressive behavior from late childhood through early adulthood

Tina Kretschmer*, Isabelle Ouellet-Morin, Charlotte Vrijen, Ilja Maria Nolte, Catharina Hartman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Twin studies suggest a substantial role for genes in explaining individual differences in aggressive behavior across development. It is unclear, however, how directly measured genetic risk is associated with aggressive behavior at different moments across adolescence and how genes might distinguish developmental trajectories of aggressive behavior. Here, a polygenic risk score derived from the EAGLE-Consortium genome-wide association study of aggressive behavior in children was tested as predictor of latent growth classes derived from those measures in an adolescent population (n = 2229, of which n = 1246 with genetic information) and a high-risk sample (n = 543, of which n = 335 with genetic information). In the population sample, the polygenic risk score explained variation in parent-reported aggressive behavior at all ages and distinguished between stable low aggressive behavior and moderate and high-decreasing trajectories based on parent-report. In contrast, the polygenic risk score was not associated with self- and teacher-reported aggressive behavior, and no associations were found in the high-risk sample. This pattern of results suggests that methodological choices made in genome-wide association studies impact the predictive strength of polygenic risk scores, not just with respect to power but likely also in terms of generalizability and specificity.

Original languageEnglish
Number of pages10
JournalEuropean Child & Adolescent Psychiatry
DOIs
Publication statusE-pub ahead of print - 6-Nov-2021

Keywords

  • Polygenic risk score
  • Aggressive behavior
  • Latent class growth model
  • INDIVIDUAL-LIVES SURVEY
  • ANTISOCIAL-BEHAVIOR
  • COHORT PROFILE
  • ADOLESCENTS
  • PERSONALITY
  • OUTCOMES
  • CONDUCT
  • SAMPLE
  • BOYS

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