Poly(l-lactic)Acid implants in repair of defects of the orbital floor: A five-year animal study

J. E. Bergsma; F. R. Rozema; R. R. M. Bos; W. C. De Bruijn; G. Boering

Poly(l-lactic)Acid implants in repair of defects of the orbital floor: A five-year animal study

J. E. Bergsma^*, F. R. Rozema, R. R. M. Bos, W. C. De Bruijn, G. Boering

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Biodegradable as-polymerized poly(l-lactic)acid (PLLA) implants were used for the repair of artificially created orbital floor defects in goats. The results of a five year histological follow-up of one animal per period are reported in this study. After 3 years of implantation the PLLA material had degraded but had not fully disintegrated into small particles. After 5 years of implantation, the PLLA was still not fully absorbed. In all sections, the implants were fully encapsulated by a fibrous tissue layer. This capsule was fully covered by newly formed bone at both the orbital and antral side. Ultrastructural investigation showed that lamellar or needlelike PLLA particles were situated between bundles of collagen and in various cells. These results are compared to our findings of an earlier study in humans.

Original language	English
Pages (from-to)	31-36
Number of pages	6
Journal	Cells and materials
Volume	4
Issue number	1
Publication status	Published - 1994

Keywords

POLY(L-LACTIC)ACID
BIODEGRADATION
BIOABSORPTION
ORBITAL FLOOR IMPLANTS
ANIMAL MODEL
FRACTURE REPAIR
ZYGOMATIC FRACTURES
LATE COMPLICATION
FIXATION
SCREWS
RECONSTRUCTION
PLATES

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@article{c6cf35e58096402596d43c6e2f678b5b,

title = "Poly(l-lactic)Acid implants in repair of defects of the orbital floor: A five-year animal study",

abstract = "Biodegradable as-polymerized poly(l-lactic)acid (PLLA) implants were used for the repair of artificially created orbital floor defects in goats. The results of a five year histological follow-up of one animal per period are reported in this study. After 3 years of implantation the PLLA material had degraded but had not fully disintegrated into small particles. After 5 years of implantation, the PLLA was still not fully absorbed. In all sections, the implants were fully encapsulated by a fibrous tissue layer. This capsule was fully covered by newly formed bone at both the orbital and antral side. Ultrastructural investigation showed that lamellar or needlelike PLLA particles were situated between bundles of collagen and in various cells. These results are compared to our findings of an earlier study in humans.",

keywords = "POLY(L-LACTIC)ACID, BIODEGRADATION, BIOABSORPTION, ORBITAL FLOOR IMPLANTS, ANIMAL MODEL, FRACTURE REPAIR, ZYGOMATIC FRACTURES, LATE COMPLICATION, FIXATION, SCREWS, RECONSTRUCTION, PLATES",

author = "Bergsma, {J. E.} and Rozema, {F. R.} and Bos, {R. R. M.} and {De Bruijn}, {W. C.} and G. Boering",

year = "1994",

language = "English",

volume = "4",

pages = "31--36",

journal = "Cells and materials",

issn = "1051-6794",

number = "1",

}

TY - JOUR

T1 - Poly(l-lactic)Acid implants in repair of defects of the orbital floor

T2 - A five-year animal study

AU - Bergsma, J. E.

AU - Rozema, F. R.

AU - Bos, R. R. M.

AU - De Bruijn, W. C.

AU - Boering, G.

PY - 1994

Y1 - 1994

N2 - Biodegradable as-polymerized poly(l-lactic)acid (PLLA) implants were used for the repair of artificially created orbital floor defects in goats. The results of a five year histological follow-up of one animal per period are reported in this study. After 3 years of implantation the PLLA material had degraded but had not fully disintegrated into small particles. After 5 years of implantation, the PLLA was still not fully absorbed. In all sections, the implants were fully encapsulated by a fibrous tissue layer. This capsule was fully covered by newly formed bone at both the orbital and antral side. Ultrastructural investigation showed that lamellar or needlelike PLLA particles were situated between bundles of collagen and in various cells. These results are compared to our findings of an earlier study in humans.

AB - Biodegradable as-polymerized poly(l-lactic)acid (PLLA) implants were used for the repair of artificially created orbital floor defects in goats. The results of a five year histological follow-up of one animal per period are reported in this study. After 3 years of implantation the PLLA material had degraded but had not fully disintegrated into small particles. After 5 years of implantation, the PLLA was still not fully absorbed. In all sections, the implants were fully encapsulated by a fibrous tissue layer. This capsule was fully covered by newly formed bone at both the orbital and antral side. Ultrastructural investigation showed that lamellar or needlelike PLLA particles were situated between bundles of collagen and in various cells. These results are compared to our findings of an earlier study in humans.

KW - POLY(L-LACTIC)ACID

KW - BIODEGRADATION

KW - BIOABSORPTION

KW - ORBITAL FLOOR IMPLANTS

KW - ANIMAL MODEL

KW - FRACTURE REPAIR

KW - ZYGOMATIC FRACTURES

KW - LATE COMPLICATION

KW - FIXATION

KW - SCREWS

KW - RECONSTRUCTION

KW - PLATES

M3 - Article

SN - 1051-6794

VL - 4

SP - 31

EP - 36

JO - Cells and materials

JF - Cells and materials

IS - 1

ER -

Poly(l-lactic)Acid implants in repair of defects of the orbital floor: A five-year animal study

Abstract

Keywords

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