Polyoxometalate Composites in Cancer Therapy and Diagnostics

Gabriela Guedes, Shiqi Wang, Hélder A. Santos, Filipa L. Sousa*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)

Abstract

Polyoxometalates (POMs) are metal‐oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti‐viral and anti‐tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM‐based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.
Original languageEnglish
Pages (from-to)2121-2132
Number of pages12
JournalEuropean Journal of Inorganic Chemistry
Volume2020
Issue number22
DOIs
Publication statusPublished - 16-Jun-2020
Externally publishedYes

Keywords

  • ANTIBACTERIAL ACTIVITY
  • BLOOD-GLUCOSE
  • NANOMATERIALS
  • NANOSTRUCTURES
  • PLATFORM
  • POLYOXOTUNGSTATE
  • Photothermal therapy
  • Polyoxometalates
  • RADIORESISTANCE
  • RADIOSENSITIZATION
  • RESISTANT STAPHYLOCOCCUS-AUREUS
  • Radiotherapy
  • Sensors
  • TUMOR MICROENVIRONMENT
  • Theranostics
  • 116 Chemical sciences
  • 3111 Biomedicine
  • 221 Nano-technology
  • 317 Pharmacy

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