Polyphenol oxidase-based electrochemical biosensors: A review

Paulo A. Raymundo-Pereira; Tiago A. Silva; Fábio R. Caetano; Laís Ribovski; Eduardo Zapp; Daniela Brondani; Marcio F. Bergamini; Luiz H. Marcolino; Craig E. Banks; Osvaldo N. Oliveira; Bruno C. Janegitz; Orlando Fatibello-Filho

doi:10.1016/j.aca.2020.07.055

Polyphenol oxidase-based electrochemical biosensors: A review

Paulo A. Raymundo-Pereira, Tiago A. Silva, Fábio R. Caetano, Laís Ribovski, Eduardo Zapp, Daniela Brondani, Marcio F. Bergamini, Luiz H. Marcolino, Craig E. Banks, Osvaldo N. Oliveira, Bruno C. Janegitz^*, Orlando Fatibello-Filho^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

Abstract

The detection of phenolic compounds is relevant not only for their possible benefits to human health but also for their role as chemical pollutants, including as endocrine disruptors. The required monitoring of such compounds on-site or in field analysis can be performed with electrochemical biosensors made with polyphenol oxidases (PPO). In this review, we describe biosensors containing the oxidases tyrosinase and laccase, in addition to crude extracts and tissues from plants as enzyme sources. From the survey in the literature, we found that significant advances to obtain sensitive, robust biosensors arise from the synergy reached with a diversity of nanomaterials employed in the matrix. These nanomaterials are mostly metallic nanoparticles and carbon nanostructures, which offer a suitable environment to preserve the activity of the enzymes and enhance electron transport. Besides presenting a summary of contributions to electrochemical biosensors containing PPOs in the last five years, we discuss the trends and challenges to take these biosensors to the market, especially for biomedical applications.

Original language	English
Pages (from-to)	198-221
Number of pages	24
Journal	Analytica Chimica Acta
Volume	1139
DOIs	https://doi.org/10.1016/j.aca.2020.07.055
Publication status	Published - 1-Dec-2020
Externally published	Yes

Keywords

Biosensors
Crude extract
Detection
Electrochemical
Laccase
Nanomaterials
Phenolic
Polyphenol oxidases: tyrosinase

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@article{e6c1c0a23d0f40259e0f93aebc215bbd,

title = "Polyphenol oxidase-based electrochemical biosensors: A review",

abstract = "The detection of phenolic compounds is relevant not only for their possible benefits to human health but also for their role as chemical pollutants, including as endocrine disruptors. The required monitoring of such compounds on-site or in field analysis can be performed with electrochemical biosensors made with polyphenol oxidases (PPO). In this review, we describe biosensors containing the oxidases tyrosinase and laccase, in addition to crude extracts and tissues from plants as enzyme sources. From the survey in the literature, we found that significant advances to obtain sensitive, robust biosensors arise from the synergy reached with a diversity of nanomaterials employed in the matrix. These nanomaterials are mostly metallic nanoparticles and carbon nanostructures, which offer a suitable environment to preserve the activity of the enzymes and enhance electron transport. Besides presenting a summary of contributions to electrochemical biosensors containing PPOs in the last five years, we discuss the trends and challenges to take these biosensors to the market, especially for biomedical applications.",

keywords = "Biosensors, Crude extract, Detection, Electrochemical, Laccase, Nanomaterials, Phenolic, Polyphenol oxidases: tyrosinase",

author = "Raymundo-Pereira, {Paulo A.} and Silva, {Tiago A.} and Caetano, {F{\'a}bio R.} and La{\'i}s Ribovski and Eduardo Zapp and Daniela Brondani and Bergamini, {Marcio F.} and Marcolino, {Luiz H.} and Banks, {Craig E.} and Oliveira, {Osvaldo N.} and Janegitz, {Bruno C.} and Orlando Fatibello-Filho",

note = "Funding Information: This work was supported by CNPq ( 303338/2019–9 , 140408/2019–3 , 405546/2018–1 and 423952/2018–8 ), INEO and FAPESP ( 2018/22214-6 , 2017/21898–6 , 2017/21097–3 , 2020/01050-5 and 2016/01919–6 ). Funding Information: This work was supported by CNPq (303338/2019?9, 140408/2019?3, 405546/2018?1 and 423952/2018?8), INEO and FAPESP (2018/22214-6, 2017/21898?6, 2017/21097?3, 2020/01050-5 and 2016/01919?6). Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.aca.2020.07.055",

language = "English",

volume = "1139",

pages = "198--221",

journal = "Analytica Chimica Acta",

issn = "0003-2670",

publisher = "ELSEVIER SCIENCE BV",

}

TY - JOUR

T1 - Polyphenol oxidase-based electrochemical biosensors

T2 - A review

AU - Raymundo-Pereira, Paulo A.

AU - Silva, Tiago A.

AU - Caetano, Fábio R.

AU - Ribovski, Laís

AU - Zapp, Eduardo

AU - Brondani, Daniela

AU - Bergamini, Marcio F.

AU - Marcolino, Luiz H.

AU - Banks, Craig E.

AU - Oliveira, Osvaldo N.

AU - Janegitz, Bruno C.

AU - Fatibello-Filho, Orlando

N1 - Funding Information: This work was supported by CNPq ( 303338/2019–9 , 140408/2019–3 , 405546/2018–1 and 423952/2018–8 ), INEO and FAPESP ( 2018/22214-6 , 2017/21898–6 , 2017/21097–3 , 2020/01050-5 and 2016/01919–6 ). Funding Information: This work was supported by CNPq (303338/2019?9, 140408/2019?3, 405546/2018?1 and 423952/2018?8), INEO and FAPESP (2018/22214-6, 2017/21898?6, 2017/21097?3, 2020/01050-5 and 2016/01919?6). Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The detection of phenolic compounds is relevant not only for their possible benefits to human health but also for their role as chemical pollutants, including as endocrine disruptors. The required monitoring of such compounds on-site or in field analysis can be performed with electrochemical biosensors made with polyphenol oxidases (PPO). In this review, we describe biosensors containing the oxidases tyrosinase and laccase, in addition to crude extracts and tissues from plants as enzyme sources. From the survey in the literature, we found that significant advances to obtain sensitive, robust biosensors arise from the synergy reached with a diversity of nanomaterials employed in the matrix. These nanomaterials are mostly metallic nanoparticles and carbon nanostructures, which offer a suitable environment to preserve the activity of the enzymes and enhance electron transport. Besides presenting a summary of contributions to electrochemical biosensors containing PPOs in the last five years, we discuss the trends and challenges to take these biosensors to the market, especially for biomedical applications.

AB - The detection of phenolic compounds is relevant not only for their possible benefits to human health but also for their role as chemical pollutants, including as endocrine disruptors. The required monitoring of such compounds on-site or in field analysis can be performed with electrochemical biosensors made with polyphenol oxidases (PPO). In this review, we describe biosensors containing the oxidases tyrosinase and laccase, in addition to crude extracts and tissues from plants as enzyme sources. From the survey in the literature, we found that significant advances to obtain sensitive, robust biosensors arise from the synergy reached with a diversity of nanomaterials employed in the matrix. These nanomaterials are mostly metallic nanoparticles and carbon nanostructures, which offer a suitable environment to preserve the activity of the enzymes and enhance electron transport. Besides presenting a summary of contributions to electrochemical biosensors containing PPOs in the last five years, we discuss the trends and challenges to take these biosensors to the market, especially for biomedical applications.

KW - Biosensors

KW - Crude extract

KW - Detection

KW - Electrochemical

KW - Laccase

KW - Nanomaterials

KW - Phenolic

KW - Polyphenol oxidases: tyrosinase

UR - http://www.scopus.com/inward/record.url?scp=85089443932&partnerID=8YFLogxK

U2 - 10.1016/j.aca.2020.07.055

DO - 10.1016/j.aca.2020.07.055

M3 - Review article

C2 - 33190704

AN - SCOPUS:85089443932

SN - 0003-2670

VL - 1139

SP - 198

EP - 221

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

Polyphenol oxidase-based electrochemical biosensors: A review

Abstract

Keywords

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