Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine

Eleonora H. Heeremans, Johannes H. Proost, Douglas J. Eleveld, Anthony R. Absalom, Michel M. R. F. Struys*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Purpose of review

Population modeling is a relatively new pharmacological discipline, the development of which has largely been stimulated by the need for accurate models for the pharmacokinetics and dynamics of anesthetic agents.

Recent findings

Population-based modeling is now considered superior to older, more traditional modeling methods. Nonlinear mixed-effect modeling - a commonly used population-based modeling approach - estimates intraindividual and interindividual variability, limits the influence of outlying samples and individuals through the use of Bayesian statistical analysis, and provides a potential means of optimizing drug delivery regimens, especially when used to define pharmacokinetic-dynamic models for target-controlled infusion systems. In addition to being used for pharmacokinetic modeling, in which the influence of factors such as age, weight and illness can be studied, it is a powerful tool for the study of the influence of multiple factors on drug pharmacodynamics.

Summary

Nonlinear mixed-effect population-based modeling has become the gold standard method of pharmacokinetic and pharmacodynamic analysis during new drug development and during subsequent pharmacological studies. Population-based modeling techniques have been applied to numerous aspects of drug delivery in anesthesia, intensive care and pain medicine.

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalCurrent opinion in anesthesiology
Volume23
Issue number4
DOIs
Publication statusPublished - Aug-2010

Keywords

  • nonlinear mixed-effects modeling
  • pharmacodynamics
  • pharmacokinetics
  • TIDAL SEVOFLURANE CONCENTRATIONS
  • BISPECTRAL INDEX
  • PROPOFOL PHARMACOKINETICS
  • INTRAVENOUS ANESTHESIA
  • CLINICAL-PHARMACOLOGY
  • DYNAMIC RELATIONSHIP
  • INHALED ANESTHETICS
  • ELDERLY-PATIENTS
  • DRUG
  • REMIFENTANIL

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