Positron emission tomography in patients with breast cancer using 18F-3 '-deoxy-3 '-fluoro-L-thymidine (18F-FLT) - a pilot study

LB Been; PH Elsinga; J de Vries; DCP Cobben; PL Jager; HJ Hoekstra; AJH Suurmeijer

doi:10.1016/j.ejso.2005.09.016

Positron emission tomography in patients with breast cancer using 18F-3 '-deoxy-3 '-fluoro-L-thymidine (18F-FLT) - a pilot study

LB Been
, PH Elsinga
, J de Vries
, DCP Cobben
, PL Jager
, HJ Hoekstra^*
, AJH Suurmeijer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

79 Citations (Scopus)

Abstract

Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.

Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla.

Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	European Journal of Surgical Oncology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.ejso.2005.09.016
Publication status	Published - Feb-2006

Keywords

F-13-FLT
breast cancer
oncology
positron emission tomography
PET
IMAGING PROLIFERATION
LUNG-TUMORS
IN-VIVO
F-18-FDG
FLUORODEOXYGLUCOSE
VALIDATION
TRACER

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@article{e14fcbe52c054e3b99eec852fddf8833,

title = "Positron emission tomography in patients with breast cancer using 18F-3 '-deoxy-3 '-fluoro-L-thymidine (18F-FLT) - a pilot study",

abstract = "Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla.Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.Conclusions: F-18-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases. (c) 2005 Elsevier Ltd. All rights reserved.",

keywords = "F-13-FLT, breast cancer, oncology, positron emission tomography, PET, IMAGING PROLIFERATION, LUNG-TUMORS, IN-VIVO, F-18-FDG, FLUORODEOXYGLUCOSE, VALIDATION, TRACER",

author = "LB Been and PH Elsinga and \{de Vries\}, J and DCP Cobben and PL Jager and HJ Hoekstra and AJH Suurmeijer",

year = "2006",

month = feb,

doi = "10.1016/j.ejso.2005.09.016",

language = "English",

volume = "32",

pages = "39--43",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

publisher = "ELSEVIER SCI LTD",

number = "1",

}

TY - JOUR

T1 - Positron emission tomography in patients with breast cancer using 18F-3 '-deoxy-3 '-fluoro-L-thymidine (18F-FLT) - a pilot study

AU - Been, LB

AU - Elsinga, PH

AU - de Vries, J

AU - Cobben, DCP

AU - Jager, PL

AU - Hoekstra, HJ

AU - Suurmeijer, AJH

PY - 2006/2

Y1 - 2006/2

N2 - Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla.Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.Conclusions: F-18-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla.Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.Conclusions: F-18-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases. (c) 2005 Elsevier Ltd. All rights reserved.

KW - F-13-FLT

KW - breast cancer

KW - oncology

KW - positron emission tomography

KW - PET

KW - IMAGING PROLIFERATION

KW - LUNG-TUMORS

KW - IN-VIVO

KW - F-18-FDG

KW - FLUORODEOXYGLUCOSE

KW - VALIDATION

KW - TRACER

U2 - 10.1016/j.ejso.2005.09.016

DO - 10.1016/j.ejso.2005.09.016

M3 - Article

SN - 0748-7983

VL - 32

SP - 39

EP - 43

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 1

ER -

Positron emission tomography in patients with breast cancer using 18F-3 '-deoxy-3 '-fluoro-L-thymidine (18F-FLT) - a pilot study

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Keywords

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