Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease

José M Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Rosa A González-Polo, José M Fuentes

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

PD (Parkinson's disease) is a neurodegenerative disorder caused by loss of dopamine-generating cells in the substantia nigra. The implication of genetic factors in the aetiology of PD has an essential importance in our understanding of the development of the disease. Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene cause late-onset PD with a clinical appearance indistinguishable from idiopathic PD. Moreover, LRRK2 has been associated with the process of autophagy regulation. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD.

Original languageEnglish
Pages (from-to)1129-33
Number of pages5
JournalBiochemical Society Transactions
Volume40
Issue number5
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Autophagy
  • Humans
  • Mutation
  • Parkinson Disease
  • Protein-Serine-Threonine Kinases

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