Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck

Johannes A. Langendijk*, Alfio Ferlito, Robert P. Takes, Juan P. Rodrigo, Carl Suarez, Primo Strojan, Missak Haigentz, Alessandra Rinaldo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors.

In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)577-585
Number of pages9
JournalOral Oncology
Volume46
Issue number8
DOIs
Publication statusPublished - Aug-2010

Keywords

  • Head and neck cancer
  • Squamous cell carcinoma
  • Postoperative radiotherapy
  • Postoperative chemoradiation
  • LOCALLY ADVANCED HEAD
  • RECURSIVE PARTITIONING ANALYSIS
  • UPPER AERODIGESTIVE TRACT
  • RANDOMIZED CLINICAL-TRIAL
  • RADIATION-THERAPY
  • ACCELERATED RADIOTHERAPY
  • SALVAGE SURGERY
  • SUPRAGLOTTIC CARCINOMAS
  • CONCOMITANT IRRADIATION
  • ADJUVANT RADIOTHERAPY

Cite this