Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir; Jay A. Tischfield; Robert A. King; Thomas V. Fernandez; Lawrence W. Brown; Keun-Ah Cheon; Barbara J. Coffey; Sebastian F. T. M. de Bruijn; Lonneke Elzerman; Blanca Garcia-Delgar; Donald L. Gilbert; Dorothy E. Grice; Julie Hagstrom; Tammy Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Young Key Kim; Young-Shin Kim; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Andreas Lamerz; Bennett Leventhal; Andrea G. Ludolph; Marcos Madruga-Garrido; Athanasios Maras; Marieke D. Messchendorp; Pablo Mir; Astrid Morer; Alexander Munchau; Tara L. Murphy; Thaira J. C. Openneer; Kerstin J. Plessen; Judith J. G. Rath; Veit Roessner; Odette Frundt; Eun-Young Shin; Deborah A. Sival; Dong-Ho Song; Jungeun Song; Anne-Marie Stolte; Jennifer Tubing; Els van den Ban; Frank Visscher; Sina Wanderer; Martin Woods; Samuel H. Zinner; Matthew W. State; Gary A. Heiman; Pieter J. Hoekstra; Andrea Dietrich

doi:10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir^*, Jay A. Tischfield, Robert A. King, Thomas V. Fernandez, Lawrence W. Brown, Keun-Ah Cheon, Barbara J. Coffey, Sebastian F. T. M. de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrom, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin KimYun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D. Messchendorp, Pablo Mir, Astrid Morer, Alexander Munchau, Tara L. Murphy, Thaira J. C. Openneer, Kerstin J. Plessen, Judith J. G. Rath, Veit Roessner, Odette Frundt, Eun-Young Shin, Deborah A. Sival, Dong-Ho Song, Jungeun Song, Anne-Marie Stolte, Jennifer Tubing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H. Zinner, Matthew W. State, Gary A. Heiman, Pieter J. Hoekstra, Andrea Dietrich

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD. (C) 2016 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	126-135
Number of pages	10
Journal	Journal of Psychiatric Research
Volume	82
DOIs	https://doi.org/10.1016/j.jpsychires.2016.07.017
Publication status	Published - Nov-2016

Keywords

Attention-deficit hyperactivity disorder
Delivery
Obsessive-compulsive disorder
Pregnancy
Prenatal
Tourette syndrome
DEFICIT HYPERACTIVITY DISORDER
PRENATAL RISK-FACTORS
TIC-SEVERITY-SCALE
LOW-BIRTH-WEIGHT
MATERNAL SMOKING
CHILDREN
ADHD
ADOLESCENTS
PREGNANCY
SYMPTOMS

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Pre- and perinatal complications in relation to Tourette syndrome
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Abdulkadir, M., Tischfield, J. A., King, R. A., Fernandez, T. V., Brown, L. W., Cheon, K.-A., Coffey, B. J., de Bruijn, S. F. T. M., Elzerman, L., Garcia-Delgar, B., Gilbert, D. L., Grice, D. E., Hagstrom, J., Hedderly, T., Heyman, I., Hong, H. J., Huyser, C., Ibanez-Gomez, L., Kim, Y. K., ... Dietrich, A. (2016). Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of Psychiatric Research, 82, 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

@article{afde8a246ad940b1bdd5897ad3a2d355,

title = "Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder",

abstract = "Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD. (C) 2016 Elsevier Ltd. All rights reserved.",

keywords = "Attention-deficit hyperactivity disorder, Delivery, Obsessive-compulsive disorder, Pregnancy, Prenatal, Tourette syndrome, DEFICIT HYPERACTIVITY DISORDER, PRENATAL RISK-FACTORS, TIC-SEVERITY-SCALE, LOW-BIRTH-WEIGHT, MATERNAL SMOKING, CHILDREN, ADHD, ADOLESCENTS, PREGNANCY, SYMPTOMS",

author = "Mohamed Abdulkadir and Tischfield, {Jay A.} and King, {Robert A.} and Fernandez, {Thomas V.} and Brown, {Lawrence W.} and Keun-Ah Cheon and Coffey, {Barbara J.} and {de Bruijn}, {Sebastian F. T. M.} and Lonneke Elzerman and Blanca Garcia-Delgar and Gilbert, {Donald L.} and Grice, {Dorothy E.} and Julie Hagstrom and Tammy Hedderly and Isobel Heyman and Hong, {Hyun Ju} and Chaim Huyser and Laura Ibanez-Gomez and Kim, {Young Key} and Young-Shin Kim and Yun-Joo Koh and Sodahm Kook and Samuel Kuperman and Andreas Lamerz and Bennett Leventhal and Ludolph, {Andrea G.} and Marcos Madruga-Garrido and Athanasios Maras and Messchendorp, {Marieke D.} and Pablo Mir and Astrid Morer and Alexander Munchau and Murphy, {Tara L.} and Openneer, {Thaira J. C.} and Plessen, {Kerstin J.} and Rath, {Judith J. G.} and Veit Roessner and Odette Frundt and Eun-Young Shin and Sival, {Deborah A.} and Dong-Ho Song and Jungeun Song and Anne-Marie Stolte and Jennifer Tubing and {van den Ban}, Els and Frank Visscher and Sina Wanderer and Martin Woods and Zinner, {Samuel H.} and State, {Matthew W.} and Heiman, {Gary A.} and Hoekstra, {Pieter J.} and Andrea Dietrich",

year = "2016",

month = nov,

doi = "10.1016/j.jpsychires.2016.07.017",

language = "English",

volume = "82",

pages = "126--135",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

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Abdulkadir, M, Tischfield, JA, King, RA, Fernandez, TV, Brown, LW, Cheon, K-A, Coffey, BJ, de Bruijn, SFTM, Elzerman, L, Garcia-Delgar, B, Gilbert, DL, Grice, DE, Hagstrom, J, Hedderly, T, Heyman, I, Hong, HJ, Huyser, C, Ibanez-Gomez, L, Kim, YK, Kim, Y-S, Koh, Y-J, Kook, S, Kuperman, S, Lamerz, A, Leventhal, B, Ludolph, AG, Madruga-Garrido, M, Maras, A, Messchendorp, MD, Mir, P, Morer, A, Munchau, A, Murphy, TL, Openneer, TJC, Plessen, KJ, Rath, JJG, Roessner, V, Frundt, O, Shin, E-Y, Sival, DA, Song, D-H, Song, J, Stolte, A-M, Tubing, J, van den Ban, E, Visscher, F, Wanderer, S, Woods, M, Zinner, SH, State, MW, Heiman, GA, Hoekstra, PJ & Dietrich, A 2016, 'Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder', Journal of Psychiatric Research, vol. 82, pp. 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. / Abdulkadir, Mohamed; Tischfield, Jay A.; King, Robert A. et al.
In: Journal of Psychiatric Research, Vol. 82, 11.2016, p. 126-135.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

AU - Abdulkadir, Mohamed

AU - Tischfield, Jay A.

AU - King, Robert A.

AU - Fernandez, Thomas V.

AU - Brown, Lawrence W.

AU - Cheon, Keun-Ah

AU - Coffey, Barbara J.

AU - de Bruijn, Sebastian F. T. M.

AU - Elzerman, Lonneke

AU - Garcia-Delgar, Blanca

AU - Gilbert, Donald L.

AU - Grice, Dorothy E.

AU - Hagstrom, Julie

AU - Hedderly, Tammy

AU - Heyman, Isobel

AU - Hong, Hyun Ju

AU - Huyser, Chaim

AU - Ibanez-Gomez, Laura

AU - Kim, Young Key

AU - Kim, Young-Shin

AU - Koh, Yun-Joo

AU - Kook, Sodahm

AU - Kuperman, Samuel

AU - Lamerz, Andreas

AU - Leventhal, Bennett

AU - Ludolph, Andrea G.

AU - Madruga-Garrido, Marcos

AU - Maras, Athanasios

AU - Messchendorp, Marieke D.

AU - Mir, Pablo

AU - Morer, Astrid

AU - Munchau, Alexander

AU - Murphy, Tara L.

AU - Openneer, Thaira J. C.

AU - Plessen, Kerstin J.

AU - Rath, Judith J. G.

AU - Roessner, Veit

AU - Frundt, Odette

AU - Shin, Eun-Young

AU - Sival, Deborah A.

AU - Song, Dong-Ho

AU - Song, Jungeun

AU - Stolte, Anne-Marie

AU - Tubing, Jennifer

AU - van den Ban, Els

AU - Visscher, Frank

AU - Wanderer, Sina

AU - Woods, Martin

AU - Zinner, Samuel H.

AU - State, Matthew W.

AU - Heiman, Gary A.

AU - Hoekstra, Pieter J.

AU - Dietrich, Andrea

PY - 2016/11

Y1 - 2016/11

N2 - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD. (C) 2016 Elsevier Ltd. All rights reserved.

AB - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD. (C) 2016 Elsevier Ltd. All rights reserved.

KW - Attention-deficit hyperactivity disorder

KW - Delivery

KW - Obsessive-compulsive disorder

KW - Pregnancy

KW - Prenatal

KW - Tourette syndrome

KW - DEFICIT HYPERACTIVITY DISORDER

KW - PRENATAL RISK-FACTORS

KW - TIC-SEVERITY-SCALE

KW - LOW-BIRTH-WEIGHT

KW - MATERNAL SMOKING

KW - CHILDREN

KW - ADHD

KW - ADOLESCENTS

KW - PREGNANCY

KW - SYMPTOMS

U2 - 10.1016/j.jpsychires.2016.07.017

DO - 10.1016/j.jpsychires.2016.07.017

M3 - Article

C2 - 27494079

SN - 0022-3956

VL - 82

SP - 126

EP - 135

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

ER -

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Abstract

Keywords

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