Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome

S. De Raedt; P. Haentjens; A. De Smedt; R. Brouns; Maarten Uyttenboogaart; G. J. Luijckx; J. De Keyser

doi:10.1111/j.1468-1331.2011.03475.x

Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome

S. De Raedt^*, P. Haentjens, A. De Smedt, R. Brouns, Maarten Uyttenboogaart, G. J. Luijckx, J. De Keyser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Background and purpose: It is unclear whether pre-stroke beta-blockers use may influence stroke outcome. This study evaluates the independent effect of pre-stroke use of beta-blockers on ischaemic stroke severity and 3 months functional outcome.

Methods: Pre-stroke use of beta-blockers was investigated in 1375 ischaemic stroke patients who had been included in two placebo-controlled trials with lubeluzole. Stroke severity was assessed by either the National Institute of Health Stroke Scale (NIHSS) or the European Stroke Scale (ESS). A modified Rankin scale (mRS) score of >3 at 3 months was used as measure for the poor functional outcome.

Results: Two hundred and sixty four patients were on beta-blockers prior to stroke onset, and 105 patients continued treatment after their stroke. Pretreatment with beta-blockers did not influence baseline stroke severity. There was no difference in stroke severity between nonusers and those on either a selective beta(1)-blocker or a nonselective beta-blocker. The likelihood of a poor outcome at 3 months was not influenced by pre-stroke beta-blocker use or beta-blocker use before and continued after stroke onset.

Conclusions: Pre-stroke use of beta-blockers does not appear to influence stroke severity and functional outcome at 3 months.

Original language	English
Pages (from-to)	234-240
Number of pages	7
Journal	European Journal of Neurology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/j.1468-1331.2011.03475.x
Publication status	Published - Feb-2012

Keywords

beta-blocker
cerebral infarction
outcome
severity
FOCAL CEREBRAL-ISCHEMIA
PROVIDES NEUROPROTECTION
ACTIVATES ASTROCYTES
BRAIN-INJURY
PROPRANOLOL
TRIAL
HYPERGLYCEMIA
CARVEDILOL
LUBELUZOLE
BLOCKADE

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@article{93ae966958964f26a53d7a9b500f7a3d,

title = "Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome",

abstract = "Background and purpose: It is unclear whether pre-stroke beta-blockers use may influence stroke outcome. This study evaluates the independent effect of pre-stroke use of beta-blockers on ischaemic stroke severity and 3 months functional outcome.Methods: Pre-stroke use of beta-blockers was investigated in 1375 ischaemic stroke patients who had been included in two placebo-controlled trials with lubeluzole. Stroke severity was assessed by either the National Institute of Health Stroke Scale (NIHSS) or the European Stroke Scale (ESS). A modified Rankin scale (mRS) score of >3 at 3 months was used as measure for the poor functional outcome.Results: Two hundred and sixty four patients were on beta-blockers prior to stroke onset, and 105 patients continued treatment after their stroke. Pretreatment with beta-blockers did not influence baseline stroke severity. There was no difference in stroke severity between nonusers and those on either a selective beta(1)-blocker or a nonselective beta-blocker. The likelihood of a poor outcome at 3 months was not influenced by pre-stroke beta-blocker use or beta-blocker use before and continued after stroke onset.Conclusions: Pre-stroke use of beta-blockers does not appear to influence stroke severity and functional outcome at 3 months.",

keywords = "beta-blocker, cerebral infarction, outcome, severity, FOCAL CEREBRAL-ISCHEMIA, PROVIDES NEUROPROTECTION, ACTIVATES ASTROCYTES, BRAIN-INJURY, PROPRANOLOL, TRIAL, HYPERGLYCEMIA, CARVEDILOL, LUBELUZOLE, BLOCKADE",

author = "{De Raedt}, S. and P. Haentjens and {De Smedt}, A. and R. Brouns and Maarten Uyttenboogaart and Luijckx, {G. J.} and {De Keyser}, J.",

note = "{\textcopyright} 2011 The Author(s). European Journal of Neurology {\textcopyright} 2011 EFNS.",

year = "2012",

month = feb,

doi = "10.1111/j.1468-1331.2011.03475.x",

language = "English",

volume = "19",

pages = "234--240",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley",

number = "2",

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T1 - Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome

AU - De Raedt, S.

AU - Haentjens, P.

AU - De Smedt, A.

AU - Brouns, R.

AU - Uyttenboogaart, Maarten

AU - Luijckx, G. J.

AU - De Keyser, J.

PY - 2012/2

Y1 - 2012/2

N2 - Background and purpose: It is unclear whether pre-stroke beta-blockers use may influence stroke outcome. This study evaluates the independent effect of pre-stroke use of beta-blockers on ischaemic stroke severity and 3 months functional outcome.Methods: Pre-stroke use of beta-blockers was investigated in 1375 ischaemic stroke patients who had been included in two placebo-controlled trials with lubeluzole. Stroke severity was assessed by either the National Institute of Health Stroke Scale (NIHSS) or the European Stroke Scale (ESS). A modified Rankin scale (mRS) score of >3 at 3 months was used as measure for the poor functional outcome.Results: Two hundred and sixty four patients were on beta-blockers prior to stroke onset, and 105 patients continued treatment after their stroke. Pretreatment with beta-blockers did not influence baseline stroke severity. There was no difference in stroke severity between nonusers and those on either a selective beta(1)-blocker or a nonselective beta-blocker. The likelihood of a poor outcome at 3 months was not influenced by pre-stroke beta-blocker use or beta-blocker use before and continued after stroke onset.Conclusions: Pre-stroke use of beta-blockers does not appear to influence stroke severity and functional outcome at 3 months.

AB - Background and purpose: It is unclear whether pre-stroke beta-blockers use may influence stroke outcome. This study evaluates the independent effect of pre-stroke use of beta-blockers on ischaemic stroke severity and 3 months functional outcome.Methods: Pre-stroke use of beta-blockers was investigated in 1375 ischaemic stroke patients who had been included in two placebo-controlled trials with lubeluzole. Stroke severity was assessed by either the National Institute of Health Stroke Scale (NIHSS) or the European Stroke Scale (ESS). A modified Rankin scale (mRS) score of >3 at 3 months was used as measure for the poor functional outcome.Results: Two hundred and sixty four patients were on beta-blockers prior to stroke onset, and 105 patients continued treatment after their stroke. Pretreatment with beta-blockers did not influence baseline stroke severity. There was no difference in stroke severity between nonusers and those on either a selective beta(1)-blocker or a nonselective beta-blocker. The likelihood of a poor outcome at 3 months was not influenced by pre-stroke beta-blocker use or beta-blocker use before and continued after stroke onset.Conclusions: Pre-stroke use of beta-blockers does not appear to influence stroke severity and functional outcome at 3 months.

KW - beta-blocker

KW - cerebral infarction

KW - outcome

KW - severity

KW - FOCAL CEREBRAL-ISCHEMIA

KW - PROVIDES NEUROPROTECTION

KW - ACTIVATES ASTROCYTES

KW - BRAIN-INJURY

KW - PROPRANOLOL

KW - TRIAL

KW - HYPERGLYCEMIA

KW - CARVEDILOL

KW - LUBELUZOLE

KW - BLOCKADE

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DO - 10.1111/j.1468-1331.2011.03475.x

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SN - 1351-5101

VL - 19

SP - 234

EP - 240

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 2

ER -

Pre-stroke use of beta-blockers does not affect ischaemic stroke severity and outcome

Abstract

Keywords

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