Preclinical studies of CD103 molecular imaging to guide cancer immunotherapy

Xiaoyu Fan

doi:10.33612/diss.776322392

Preclinical studies of CD103 molecular imaging to guide cancer immunotherapy

Xiaoyu Fan

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

In summary, this study aims to lay the foundation for the clinical application of CD103 immune PET by developing various tracer types and conducting preliminary in vivo exploration using animal models. It is our hope that these humanized CD103 immune PET tracers can non-invasively assess tumor-reactive T cell infiltration in patients, stratifying those who may benefit from immune checkpoint inhibitor therapy, ultimately providing further benefits to cancer patients.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Elsinga, Philip, Supervisor Nijman, Hans, Supervisor de Bruyn, Marco, Co-supervisor
Award date	16-Oct-2023
Place of Publication	[Groningen]
Publisher	University of Groningen
DOIs	https://doi.org/10.33612/diss.776322392
Publication status	Published - 2023

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10.33612/diss.776322392

Title and contentsFinal publisher's version, 25.4 MB
Chapter 1Final publisher's version, 1.4 MB
Chapter 2Final publisher's version, 2.04 MB
Chapter 3Final publisher's version, 5.91 MB
Chapter 5Final publisher's version, 4.47 MB
Chapter 6Final publisher's version, 2.41 MB
AppendixFinal publisher's version, 1.89 MB
Complete thesisFinal publisher's version, 35.2 MB
PropositionsFinal publisher's version, 300 KB

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title = "Preclinical studies of CD103 molecular imaging to guide cancer immunotherapy",

abstract = "In summary, this study aims to lay the foundation for the clinical application of CD103 immune PET by developing various tracer types and conducting preliminary in vivo exploration using animal models. It is our hope that these humanized CD103 immune PET tracers can non-invasively assess tumor-reactive T cell infiltration in patients, stratifying those who may benefit from immune checkpoint inhibitor therapy, ultimately providing further benefits to cancer patients.",

author = "Xiaoyu Fan",

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language = "English",

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school = "University of Groningen",

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AB - In summary, this study aims to lay the foundation for the clinical application of CD103 immune PET by developing various tracer types and conducting preliminary in vivo exploration using animal models. It is our hope that these humanized CD103 immune PET tracers can non-invasively assess tumor-reactive T cell infiltration in patients, stratifying those who may benefit from immune checkpoint inhibitor therapy, ultimately providing further benefits to cancer patients.

U2 - 10.33612/diss.776322392

DO - 10.33612/diss.776322392

M3 - Thesis fully internal (DIV)

PB - University of Groningen

CY - [Groningen]

ER -

Preclinical studies of CD103 molecular imaging to guide cancer immunotherapy

Abstract

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