Preconception environmental factors and placental morphometry in relation to pregnancy outcome

Nastaran Salavati

    Research output: ThesisThesis fully internal (DIV)

    1113 Downloads (Pure)


    In this thesis, the relation between both preconception environmental factors (including air pollution, and maternal dietary intake) and that of placental morphometry with pregnancy outcome was investigated.
    It has been quite well established that maternal dietary intake during pregnancy is associated with pregnancy outcome. However, during the past few years there is increased recognition that maternal dietary intake already from preconception onwards may affect pregnancy outcome. Literature investigating this association is still scarce. Therefore we created the ‘Perined-Lifelines birth cohort’ by linking the Dutch national birth registry (Perined) with a large population-based cohort study (The Lifelines Cohort study) through a ‘trusted third party’ with the aim to provide insights on the associations between maternal dietary intake before conception and pregnancy outcome. Within this birth cohort we observed that maternal dietary intake during preconception was associated with birth weight of the offspring. Interestingly, specifically within the group of women with the lowest BMI in our cohort, higher intake of specific macronutrients was associated with increased birth weight of their offspring. We recommend that any dietary assessment and advise during preconception should be customized to preconception weight status of the women.

    Secondly, we demonstrated that both ultrasonic fetal biometry and Doppler flow velocimetry are associated with placental morphometry after birth. In addition, the possible use of placental morhometry in detection of fetal growth restriction was investigated. Parameters such as placental surface area, placental volume in relation to birth weight can help to identify newborns who might have encountered fetal growth restriction and need accurate monitoring after birth.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • Erwich, Jan Jaap, Supervisor
    • van der Beek, Eline, Supervisor
    • Bakker, Marian, Co-supervisor
    • Gordijn, Sanne, Co-supervisor
    Award date27-Jan-2020
    Place of Publication[Groningen]
    Print ISBNs978-94-6375-696-9
    Publication statusPublished - 2020


    Dive into the research topics of 'Preconception environmental factors and placental morphometry in relation to pregnancy outcome'. Together they form a unique fingerprint.

    Cite this