Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia

M. Hara, K. Masui*, D. J. Eleveld, M. M. R. F. Struys, O. Uchida

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)


Background. Predictive performance of eleven published propofol pharmacokinetic models was evaluated for long-duration propofol infusion in children.

Methods. Twenty-one aged three-11 yr ASA I-II patients were included. Anaesthesia was induced with propofol or sevoflurane, and maintained with propofol, remifentanil, and fentanyl. Propofol was continuously infused at rates of 4-14mg kg(-1) h(-1) after an initial bolus of 1.5-2.0mg kg(-1). Venous blood samples were obtained every 30-60 min for five h and then every 60-120 min after five h from the start of propofol administration, and immediately after the end of propofol administration. Model performance was assessed with prediction error (PE) derivatives including divergence PE, median PE (MDPE), and median absolute PE (MDAPE) as time-related PE shift, measures for bias, and inaccuracy, respectively.

Results. We collected 85 samples over 270 (130) (88-545), mean (SD) (range), min. The Short model for children, and the Schuttler general-purpose model had acceptable performance (-20%

Conclusions. The Short model performed well during continuous infusion up to 545 min. This model might be preferable for target-controlled infusion for long-duration anaesthesia in children.

Original languageEnglish
Pages (from-to)415-423
Number of pages9
JournalBritish Journal of Anaesthesia
Issue number3
Publication statusPublished - Mar-2017


  • paediatrics
  • pharmacokinetics
  • propofol

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